SCN5A

Gene Symbol SCN5A
Entrez Gene 6331
Alt Symbol CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1
Species Human
Gene Type protein-coding
Description sodium channel, voltage gated, type V alpha subunit
Other Description cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit|sodium channel protein cardiac muscle subunit alpha|sodium channel protein type 5 subunit alpha|sodium channel, voltage-gated, type V, alpha subunit|voltage-gated sodium channel subunit alpha Nav1.5
Swissprots E7ET19 B2RTU0 A6N922 Q75RX9 E9PEK2 Q8IZC9 Q86UR3 Q14524 A6N923 Q59H93 Q96J69 Q75RY0 E9PFW7 E9PEF3 A5H1P8
Accessions AAZ06802 ABN05288 ABO31246 ABQ01244 ADC96632 EAW64540 EAW64541 EAW64542 Q14524 AB158469 BAD12084 AB158470 BAD12085 AB208866 BAD92103 AF482988 AAO91669 AJ310886 CAC84529 AJ310887 CAC84530 AJ310888 CAC84531 AJ310889 CAC84532 AJ310890 CAC84533 AJ310891 CAC84534 AJ310892 CAC84535 AJ310893 CAC84525 AJ310894 AJ310895 AJ310896 CAC84536 AY038064 AAK74065 AY148488 AAN61120 BC051374 AAH51374 BC140813 AAI40814 BC144621 AAI44622 BU845010 EF092292 ABN50061 EF092293 ABN50062 EF092294 ABN50063 EF092295 ABN50064 EF629346 ABR15763 EF629347 ABR15764 GU014840 ACX32327 GU447319 GU447320 KC858891 AGR66220 M77235 AAA58644 XM_006713282 XP_006713345 XM_011533991 XP_011532293 XM_011533992 XP_011532294 NM_000335 NP_000326 NM_001099404 NP_001092874 NM_001099405 NP_001092875 NM_001160160 NP_001153632 NM_001160161 NP_001153633 NM_198056 NP_932173
Function This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. {ECO:0000269|PubMed:19074138}.
Subcellular Location Membrane {ECO:0000269|PubMed:19074138}; Multi-pass membrane protein {ECO:0000269|PubMed:19074138}.
Tissue Specificity Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain. {ECO:0000269|PubMed:12358675}.
Top Pathways Adrenergic signaling in cardiomyocytes

Na + CP type Vα CRISPR/Cas9 KO Plasmid (h) - sc-402162 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Na + CP type Vα HDR Plasmid (h) - sc-402162-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Na + CP type Vα Double Nickase Plasmid (h) - sc-402162-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Na + CP type Vα Double Nickase Plasmid (h2) - sc-402162-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Na + CP type Vα CRISPR Activation Plasmid (h) - sc-402162-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Na + CP type Vα CRISPR Activation Plasmid (h2) - sc-402162-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Na + CP type Vα Lentiviral Activation Particles (h) - sc-402162-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Na + CP type Vα Lentiviral Activation Particles (h2) - sc-402162-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Na + CP type Vα siRNA (h) - sc-42640 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Na + CP type Vα shRNA Plasmid (h) - sc-42640-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Na + CP type Vα shRNA (h) Lentiviral Particles - sc-42640-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nav1.5 RNAi - H00006331-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Nav1.5 RNAi - H00006331-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU151881 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1681 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1681 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11174 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11174

SCN5A siRNA (Human) - CRH4267 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SCN5A - MBS828360 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SCN5A (NM_000335.4) - SHH402880 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SCN5A(NM_000335.4) - SHR208838 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SCN5A(NM_198056.2) - SHR208968 from Creative biogene

Category siRNA
Species Reactivities Human

Human SCN5A siRNA - orb264769 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SCN5A shRNA Plasmid (Human) - CHH4267 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SCN5A miRNA 3'UTR clone - MiUTR1H-09189 from Creative biogene

Species Reactivities Human
Search more