Gene Symbol | OXSM |
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Entrez Gene | 54995 |
Alt Symbol | FASN2D, KASI, KS |
Species | Human |
Gene Type | protein-coding |
Description | 3-oxoacyl-ACP synthase, mitochondrial |
Other Description | 3-ketoacyl-acyl carrier protein synthase|3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial|3-oxoacyl-acyl-carrier-protein synthase|acyl-malonyl acyl carrier protein-condensing enzyme|beta-ketoacyl synthase|beta-ketoacyl-ACP synthase|type II mitochondrial beta-ketoacyl synthase |
Swissprots | Q9NWU1 |
Accessions | CAD22819 CAD22820 CBN69072 CBN70680 EAW64367 EAW64368 EAW64369 Q9NWU1 AK000611 BAA91286 AK225260 AK304821 BAG65569 BC008202 AAH08202 DA916187 JF432169 ADZ15386 XM_006713216 XP_006713279 XM_006713217 XP_006713280 NM_001145391 NP_001138863 NM_017897 NP_060367 NR_026937 |
Function | May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. {ECO:0000269|PubMed:15668256}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:15668256}. |
Tissue Specificity | Widely expressed. Higher expression in heart, skeletal muscle, liver and kidney which contain high levels of active mitochondria. {ECO:0000269|PubMed:15668256}. |
Top Pathways | Biotin metabolism, Fatty acid biosynthesis, Fatty acid metabolism |
β-ketoacyl synthase siRNA (h) - sc-77981 from Santa Cruz Biotechnology
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β-ketoacyl synthase shRNA Plasmid (h) - sc-77981-SH from Santa Cruz Biotechnology
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β-ketoacyl synthase shRNA (h) Lentiviral Particles - sc-77981-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU039601 from Sigma-Aldrich
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MISSION® siRNA - SIHK1479 from Sigma-Aldrich
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MISSION® siRNA - SIHK1478 from Sigma-Aldrich
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MISSION® siRNA - SIHK1477 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16220 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16220 from Sigma-Aldrich
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OXSM siRNA (Human) - CRJ0390 from Cohesion Biosciences
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shRNA set against Human OXSM (NM_017897.2) - SHH369376 from Creative biogene
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OXSM shRNA Plasmid (Human) - CHJ0390 from Cohesion Biosciences
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OXSM miRNA 3'UTR clone - MiUTR4H-TG06360 from Creative biogene
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