| Gene Symbol |
RNASE2
|
| Entrez Gene |
6036
|
| Alt Symbol |
EDN, RAF3, RNS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
|
| Other Description |
RNase 2|RNase UpI-2|eosinophil-derived neurotoxin|non-secretory ribonuclease|ribonuclease 2|ribonuclease A F3|ribonuclease US
|
| Swissprots |
Q9H2B7 P10153 Q52M39 Q9UCG7
|
| Accessions |
AAG31577 AAG31578 AAG31579 AAG31580 AAG31581 AAG31582 AAG31583 AAG31584 AAG31585 CAA34546 CAA39459 CAC27640 CDG31919 EAW66435 P10153 BC093678 AAH93678 BC093680 AAH93680 BC096059 AAH96059 M24157 AAA52337 M28129 AAA50284 M30510 AAC82505 X55988 CAA39460 NM_002934 NP_002925
|
| Function |
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. {ECO:0000269|PubMed:12578357, ECO:0000269|PubMed:3458170}.
|
| Subcellular Location |
Lysosome {ECO:0000305}. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
|
| Tissue Specificity |
Liver, lung, spleen, leukocytes and body fluids.
|