ITGA7

Gene Symbol ITGA7
Entrez Gene 3679
Alt Symbol -
Species Human
Gene Type protein-coding
Description integrin, alpha 7
Other Description integrin alpha 7 chain|integrin alpha-7
Swissprots C9JMZ6 Q13683 C9JMD3 Q86W93 B4E3U0 O43197 Q9UEV2 Q9NY89 Q9UET0
Accessions CAB41534 CAB41535 EAW96819 EAW96820 EAW96821 EAW96822 EAW96823 Q13683 AB210036 BAE06118 AF032108 AAC39708 AF034833 AAB87696 AF052050 AAC18968 AF072132 AAC80458 AK022548 BAG51088 AK057949 AK304864 BAG65602 AY358882 AAQ89241 BC050280 AAH50280 DA096702 DA398527 X74295 CAA52348 XM_005268839 XP_005268896 XM_005268840 XP_005268897 XM_005268841 XP_005268898 XM_005268842 XP_005268899 XM_005268844 XP_005268901 XM_005268845 XP_005268902 XM_005268846 XP_005268903 XM_005268847 XP_005268904 XM_005268848 XP_005268905 XM_005268849 XP_005268906 XM_005268850 XP_005268907 XM_011538286 XP_011536588 XM_011538287 XP_011536589 NM_001144996 NP_001138468 NM_001144997 NP_001138469 NM_002206 NP_002197
Function Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle. {ECO:0000269|PubMed:8626012}.
Top Pathways Focal adhesion, ECM-receptor interaction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

Integrin α7 (L-17) - sc-27706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin α7 (L-17): sc-27706. Western blot analysis of Integrin α7 expression in SW480 whole cell lysate (A) and human heart tissue extracts (B).

Integrin α7 (H-40) - sc-50431 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Integrin α7 (H-40): sc-50431. Western blot analysis of Integrin α7 expression in ACHN whole cell lysate.

Integrin α7 (C-15) - sc-27710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Integrin α7 (012-Z) - sc-81807 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α7 (012-Z): sc-81807. Western blot analysis of Integrin α7 expression in Jurkat whole cell lysate.

Anti-ITGA7 antibody - ab75224 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab75224 staining ITGA7 (green) in Human skeletal muscle tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with methacarn and blocked with 10% serum for 20 minutes at 22°C; antigen retrieval was by heat mediation in a tris buffer. Samples were incubated with primary antibody (1/100) for 12 hours. An Alexa Fluor® 488-conjugated Goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody. 10x objective.See Abreview

Anti-ITGA7 antibody - ab203254 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung carcinoma tissue sections labeling ITGA7 with ab203254 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-ITGA7 antibody - ab182941 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ITGA7 antibody (ab182941) at 0.5 µg/mlLane 1 : 293T cell lysateLane 2 : A431 cell lysateLane 3 : HeLa cell lysateLane 4 : Jurkat cell lysateLane 5 : Raji cell lysate

Anti-ITGA7 antibody - ab55351 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ITGA7 antibody [3C12] - ab195959 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3C12
Flow Cytometrical analysis of C2C12 cells labeling ITGA7 with ab195959 at 20 μg or an isotypic control.

Anti-ITGA7 antibody - N-terminal - ab138752 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ITGA7 antibody - N-terminal (ab138752) at 1/100 dilution + CEM cell lysate at 35 µg

Anti-ITGA7 / Integrin Alpha 7 Antibody (clone 8G2) IHC-plus™ - LS-B11721 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 8G2
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-ITGA7 / Integrin Alpha 7 Antibody (clone 3C12, FITC) - LS-C179570 from LifeSpan Bioscience

Prices $285.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3C12

Anti-ITGA7 / Integrin Alpha 7 Antibody (clone 3C12, PE) - LS-C179571 from LifeSpan Bioscience

Prices $345.00
Sizes 50 tst
Host Mouse
Clonality Monoclonal
Clone 3C12

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa228-257, AP) - LS-C260481 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa228-257, APC) - LS-C260484 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa228-257, Biotin) - LS-C260486 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa228-257, FITC) - LS-C260487 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa228-257, Azide-free, HRP) - LS-C260488 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa228-257, PE) - LS-C260489 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGA7 / Integrin Alpha 7 Antibody (clone 6A11) - LS-C179572 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6A11

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa197-246) - LS-C135177 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ITGA7 antibody LS-C135177 Western blot of Rat Liver lysate. Antibody concentration 1 ug/ml.

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa940-989) - LS-C121081 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from COS7 cells, treated with etoposide 25 uM 1h, using ITGA7 (light chain, Cleaved-Glu959) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa228-257) - LS-C329700 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ITGA7 / Integrin Alpha 7 Antibody (aa1123-1139) - LS-C313325 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of ITGA7 / Integrin Alpha 7 antibody. Lane 1: 293T Cell Lysate. Lane 2: A431 Cell Lysate. Lane 3: HELA Cell Lysate. Lane 4: JURKAT Cell Lysate. Lane 5: RAJI Cell Lysate.

Anti-ITGA7 / Integrin Alpha 7 Antibody (Glu959) - LS-C341180 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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