ITGA7

Gene Symbol ITGA7
Entrez Gene 3679
Alt Symbol -
Species Human
Gene Type protein-coding
Description integrin, alpha 7
Other Description integrin alpha 7 chain|integrin alpha-7
Swissprots C9JMZ6 Q13683 C9JMD3 Q86W93 B4E3U0 O43197 Q9UEV2 Q9NY89 Q9UET0
Accessions CAB41534 CAB41535 EAW96819 EAW96820 EAW96821 EAW96822 EAW96823 Q13683 AB210036 BAE06118 AF032108 AAC39708 AF034833 AAB87696 AF052050 AAC18968 AF072132 AAC80458 AK022548 BAG51088 AK057949 AK304864 BAG65602 AY358882 AAQ89241 BC050280 AAH50280 DA096702 DA398527 X74295 CAA52348 XM_005268839 XP_005268896 XM_005268840 XP_005268897 XM_005268841 XP_005268898 XM_005268842 XP_005268899 XM_005268844 XP_005268901 XM_005268845 XP_005268902 XM_005268846 XP_005268903 XM_005268847 XP_005268904 XM_005268848 XP_005268905 XM_005268849 XP_005268906 XM_005268850 XP_005268907 XM_011538286 XP_011536588 XM_011538287 XP_011536589 NM_001144996 NP_001138468 NM_001144997 NP_001138469 NM_002206 NP_002197
Function Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle. {ECO:0000269|PubMed:8626012}.
Top Pathways Focal adhesion, ECM-receptor interaction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy

Human ITGA7 protein fragment - ab114551 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE Stained with Coomassie Blue showing ab114551.

ITGA7 / Integrin Alpha 7 Antibody Blocking Peptide - LS-E6198 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

ITGA7 / Integrin Alpha 7 Antibody Blocking Peptide - LS-E16566 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Integrin alpha 7 Protein - H00003679-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

ITGA7-Antibody-N-term-Blocking-Peptide - BP18839a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

ITGA7 peptide - orb217477 from Biorbyt

Category Peptide
Prices $272.00, $510.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat

Itga7 Blocking Peptide - 33R-1785 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

Integrin alpha-7 / ITGA7 - H00003679-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Integrin alpha-7 / ITGA7 - H00003679-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Integrin alpha-7 fusion protein - ag19772 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Integrin alpha-7 fusion protein - Ag19777 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human ITGA7 - ITGA7-28842TH from Creative Biomart

Category Protein
Source Wheat germ

Integrin alpha 7 LC Blocking Peptide - CBP1614 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat

Integrin α7 (E959) Peptide - BS7058P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

Recombinant Human Integrin alpha-7(ITGA7) ,partial - CSB-YP618797HU CSB-EP618797HU CSB-BP618797HU CSB-MP618797HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Integrin alpha 7 Recombinant Protein Antigen - NBP1-86118PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

ITGA7-Blocking-Peptide-C-term - BP21366b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

ITGA7-Blocking-Peptide-N-term - BP21359a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

ITGA7 Peptide, Human - M34GP07792H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Integrin isoform alpha-7X2B beta 1 Recombinant Protein - 96-908 from ProSci

Category Protein
Prices $525.00
Sizes 100 µg
Source HEK293 cells
Species Human
Human ITGA7X2B & ITGB1 Heterodimer Protein on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Integrin alpha-7 (ITGA7), partial, Recombinant Protein - MBS1328883 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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