| Gene Symbol |
Nudt16
|
| Entrez Gene |
75686
|
| Alt Symbol |
2310041H06Rik, 2810047L04Rik, 2900006H04Rik, AI851783
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nudix (nucleoside diphosphate linked moiety X)-type motif 16
|
| Other Description |
IDP phosphatase|IDPase|U8 snoRNA-decapping enzyme|inosine diphosphate phosphatase|m7GpppN-mRNA hydrolase|nucleoside diphosphate-linked moiety X motif 16|nudix motif 16
|
| Swissprots |
Q6P3D0 Q9D716
|
| Accessions |
EDL21100 EDL21101 Q6P3D0 AA204539 AK009737 BAB26469 AK012920 AK013493 AK210027 BB027928 BC064048 AAH64048 XM_006511845 XP_006511908 NM_029385 NP_083661
|
| Function |
RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxygu
|
| Subcellular Location |
Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localized predominantly in the cytoplasm. Localized in nucleolus, and in a minor proportion in distinct foci in the nucleoplasm (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, testis, spleen, lung, heart, liver, kidney and muscle (at protein level). {ECO:0000269|PubMed:21070968}.
|
| Top Pathways |
RNA degradation, Purine metabolism
|
