DIABLO

Gene Symbol	DIABLO
Entrez Gene	56616
Alt Symbol	DFNA64, SMAC
Species	Human
Gene Type	protein-coding
Description	diablo, IAP-binding mitochondrial protein
Other Description	diablo homolog, mitochondrial|direct IAP-binding protein with low pI|second mitochondria-derived activator of caspase
Swissprots	Q9HAV6 Q9BT11 B2RDQ0 Q6W3F3 Q96LV0 Q9NR28
Accessions	EAW98311 EAW98312 EAW98313 EAW98314 EAW98315 EAW98316 Q9NR28 AF262240 AAF87716 AF298770 AAG22077 AK001399 BAG50903 AK024768 BAB14994 AK057778 BAB71568 AK222664 BAD96384 AK315629 BAG37997 AY313210 AAQ86939 BC004417 AAH04417 BC011909 AAH11909 BC046209 BC095468 AAH95468 BF313712 BF724951 BM746689 CD742753 CF128595 DA877400 DA910387 DA915183 DB254800 DQ893061 ABM83987 DQ896313 ABM87312 JX679472 AFX61342 N66735 NM_001278302 NP_001265231 NM_001278303 NP_001265232 NM_001278304 NP_001265233 NM_001278342 NP_001265271 NM_019887 NP_063940 NM_138930 NP_620308 NM_138929
Function	Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016, ECO:0000269|PubMed:15200957}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:14523016}. Note=Released into the cytosol when cells undergo apoptosis.
Tissue Specificity	Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Smac / Diablo full length protein - ab116425 from Abcam Category Protein Source E. coli Species Human

Human Smac / Diablo full length protein - ab87850 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

Human Smac / Diablo full length protein - ab87721 from Abcam Category Protein Source E. coli Species Human

Human Smac / Diablo peptide - ab66289 from Abcam Category Peptide

Smac / Diablo peptide - ab2450 from Abcam Category Peptide

Smac / Diablo peptide - ab8380 from Abcam Category Peptide

Smac / Diablo peptide - ab8381 from Abcam Category Peptide

DIABLO / SMAC Antibody Blocking Peptide - LS-E10616 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DIABLO / SMAC Antibody Blocking Peptide - LS-E29958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DIABLO / SMAC Antibody Blocking Peptide - LS-E29959 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SMAC/Diablo Partial Recombinant Protein - H00056616-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SMAC/Diablo Peptide - NBP1-76773PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Recombinant Human SMAC/Diablo Protein - NBC1-18509 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

SMAC/Diablo Recombinant Protein - P5184 from Novus Biologicals Category Protein Prices $369.00 Sizes 50 µg Species Human

Recombinant Human SMAC/Diablo Protein - P3525 from Novus Biologicals Category Protein Prices $669.00 Sizes 100 µg Source E. coli Species Human

SMAC/Diablo Recombinant Protein - P3733 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

SMAC-Antibody-C-term-Blocking-Peptide - BP6820b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Diablo peptide - GTX22450 from GeneTex Category Peptide Prices $179.00 Sizes 500 μl Species Human

Diablo peptide - GTX28380 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Diablo peptide - GTX28381 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Recombinant Human SMAC/Diablo, CF - 789-SM-100 from R&D Systems Category Protein Source E. coli-derived, Ala56-Asp239, with a C-terminal 6-His tag

SMAC/DIABLO Protein (OPPA01764) - OPPA01764 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human SMAC protein - orb81365 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

DIABLO Blocking Peptide - 33R-5520 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SMAC Blocking Peptide - 33R-10705 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

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