DIABLO

Gene Symbol	DIABLO
Entrez Gene	56616
Alt Symbol	DFNA64, SMAC
Species	Human
Gene Type	protein-coding
Description	diablo, IAP-binding mitochondrial protein
Other Description	diablo homolog, mitochondrial|direct IAP-binding protein with low pI|second mitochondria-derived activator of caspase
Swissprots	Q9HAV6 Q9BT11 B2RDQ0 Q6W3F3 Q96LV0 Q9NR28
Accessions	EAW98311 EAW98312 EAW98313 EAW98314 EAW98315 EAW98316 Q9NR28 AF262240 AAF87716 AF298770 AAG22077 AK001399 BAG50903 AK024768 BAB14994 AK057778 BAB71568 AK222664 BAD96384 AK315629 BAG37997 AY313210 AAQ86939 BC004417 AAH04417 BC011909 AAH11909 BC046209 BC095468 AAH95468 BF313712 BF724951 BM746689 CD742753 CF128595 DA877400 DA910387 DA915183 DB254800 DQ893061 ABM83987 DQ896313 ABM87312 JX679472 AFX61342 N66735 NM_001278302 NP_001265231 NM_001278303 NP_001265232 NM_001278304 NP_001265233 NM_001278342 NP_001265271 NM_019887 NP_063940 NM_138930 NP_620308 NM_138929
Function	Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016, ECO:0000269|PubMed:15200957}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:14523016}. Note=Released into the cytosol when cells undergo apoptosis.
Tissue Specificity	Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® Smac siRNA (Human Specific) - 6453 from Cell Signaling Technology Category siRNA

Smac CRISPR/Cas9 KO Plasmid (h) - sc-402009 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Smac HDR Plasmid (h) - sc-402009-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smac Double Nickase Plasmid (h) - sc-402009-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smac Double Nickase Plasmid (h2) - sc-402009-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smac CRISPR Activation Plasmid (h) - sc-402009-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Smac CRISPR Activation Plasmid (h2) - sc-402009-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Smac Lentiviral Activation Particles (h) - sc-402009-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smac Lentiviral Activation Particles (h2) - sc-402009-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Smac siRNA (h) - sc-36505 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Smac shRNA Plasmid (h) - sc-36505-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Smac shRNA (h) Lentiviral Particles - sc-36505-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMAC/Diablo RNAi - H00056616-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SMAC/Diablo RNAi - H00056616-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU145751 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1590 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1590 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05770 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr05770

DIABLO siRNA (Human) - CRJ1152 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SMAC/Diablo RNAi - H00056616-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

DIABLO - MBS8206793 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human DIABLO (NM_019887.4) - SHH278005 from Creative biogene Category siRNA Species Reactivities Human

DIABLO shRNA Plasmid (Human) - CHJ1152 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

DIABLO miRNA 3'UTR clone - MiUTR3H-07483 from Creative biogene Species Reactivities Human

DIABLO miRNA 3'UTR clone - MiUTR3H-07484 from Creative biogene Species Reactivities Human

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