Gene Symbol | EDC4 |
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Entrez Gene | 23644 |
Alt Symbol | GE1, Ge-1, HEDL5, HEDLS, RCD-8, RCD8 |
Species | Human |
Gene Type | protein-coding |
Description | enhancer of mRNA decapping 4 |
Other Description | autoantigen Ge-1|autoantigen RCD-8|enhancer of mRNA-decapping protein 4|human enhancer of decapping large subunit |
Swissprots | Q6P2E9 Q7Z6H7 Q13826 A6NGM1 Q13025 A8K4T4 Q6ZR12 |
Accessions | EAW83183 Q6P2E9 AI076562 AI631525 AK128582 AK291049 BAF83738 AK302563 BAH13744 BC043616 AAH43616 BC053598 AAH53598 BC064567 AAH64567 BX445706 DC403765 L26339 AAA21833 U17474 AAB51444 NM_014329 NP_055144 |
Function | In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro). {ECO:0000269|PubMed:16364915}. |
Subcellular Location | Cytoplasm, P-body. Nucleus. |
Top Pathways | RNA degradation |
Edc4 CRISPR/Cas9 KO Plasmid (h) - sc-403803 from Santa Cruz Biotechnology
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Edc4 HDR Plasmid (h) - sc-403803-HDR from Santa Cruz Biotechnology
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Edc4 Double Nickase Plasmid (h) - sc-403803-NIC from Santa Cruz Biotechnology
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Edc4 Double Nickase Plasmid (h2) - sc-403803-NIC-2 from Santa Cruz Biotechnology
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Edc4 CRISPR Activation Plasmid (h) - sc-403803-ACT from Santa Cruz Biotechnology
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Edc4 CRISPR Activation Plasmid (h2) - sc-403803-ACT-2 from Santa Cruz Biotechnology
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Edc4 Lentiviral Activation Particles (h) - sc-403803-LAC from Santa Cruz Biotechnology
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Edc4 Lentiviral Activation Particles (h2) - sc-403803-LAC-2 from Santa Cruz Biotechnology
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Edc4 siRNA (h) - sc-93079 from Santa Cruz Biotechnology
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Edc4 shRNA Plasmid (h) - sc-93079-SH from Santa Cruz Biotechnology
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Edc4 shRNA (h) Lentiviral Particles - sc-93079-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU094431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7648 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7648 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02750 from Sigma-Aldrich
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EDC4 siRNA (Human) - CRH8418 from Cohesion Biosciences
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EDC4 - MBS8229244 from MyBioSource
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Edc4 CRISPR/Cas9 KO Plasmid (h2) - sc-403803-KO-2 from Santa Cruz Biotechnology
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Edc4 HDR Plasmid (h2) - sc-403803-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human EDC4 (NM_014329.4) - SHH283093 from Creative biogene
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EDC4 shRNA Plasmid (Human) - CHH8418 from Cohesion Biosciences
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EDC4 miRNA 3'UTR clone - MiUTR3H-08155 from Creative biogene
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