| Gene Symbol |
KRT75
|
| Entrez Gene |
9119
|
| Alt Symbol |
K6HF, KB18, PFB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin 75, type II
|
| Other Description |
CK-75|K75|cytokeratin type II|cytokeratin-75|hK6hf|keratin, type II cytoskeletal 75|keratin-6 hair follicle|keratin-75|type II keratin-18|type II keratin-K6hf|type-II keratin Kb18
|
| Swissprots |
Q9NSA9 B4DQU4 O95678
|
| Accessions |
CAB76832 EAW96625 O95678 AK225962 AK298960 BAG61056 BC160175 AAI60175 Y17282 CAA76730 NM_004693 NP_004684
|
| Function |
Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
|
| Tissue Specificity |
Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level). {ECO:0000269|PubMed:14675170, ECO:0000269|PubMed:15292489, ECO:0000269|PubMed:18032949, ECO:0000269|PubMed:9856802}.
|