Gene Symbol | KRT75 |
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Entrez Gene | 9119 |
Alt Symbol | K6HF, KB18, PFB |
Species | Human |
Gene Type | protein-coding |
Description | keratin 75, type II |
Other Description | CK-75|K75|cytokeratin type II|cytokeratin-75|hK6hf|keratin, type II cytoskeletal 75|keratin-6 hair follicle|keratin-75|type II keratin-18|type II keratin-K6hf|type-II keratin Kb18 |
Swissprots | Q9NSA9 B4DQU4 O95678 |
Accessions | CAB76832 EAW96625 O95678 AK225962 AK298960 BAG61056 BC160175 AAI60175 Y17282 CAA76730 NM_004693 NP_004684 |
Function | Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle. |
Tissue Specificity | Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level). {ECO:0000269|PubMed:14675170, ECO:0000269|PubMed:15292489, ECO:0000269|PubMed:18032949, ECO:0000269|PubMed:9856802}. |
Keratin 75 CRISPR/Cas9 KO Plasmid (h) - sc-406498 from Santa Cruz Biotechnology
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Keratin 75 HDR Plasmid (h) - sc-406498-HDR from Santa Cruz Biotechnology
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Keratin 75 Double Nickase Plasmid (h) - sc-406498-NIC from Santa Cruz Biotechnology
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Keratin 75 Double Nickase Plasmid (h2) - sc-406498-NIC-2 from Santa Cruz Biotechnology
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Keratin 75 CRISPR Activation Plasmid (h) - sc-406498-ACT from Santa Cruz Biotechnology
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Keratin 75 CRISPR Activation Plasmid (h2) - sc-406498-ACT-2 from Santa Cruz Biotechnology
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Keratin 75 Lentiviral Activation Particles (h) - sc-406498-LAC from Santa Cruz Biotechnology
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Keratin 75 Lentiviral Activation Particles (h2) - sc-406498-LAC-2 from Santa Cruz Biotechnology
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Keratin 75 siRNA (h) - sc-105591 from Santa Cruz Biotechnology
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Keratin 75 shRNA Plasmid (h) - sc-105591-SH from Santa Cruz Biotechnology
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Keratin 75 shRNA (h) Lentiviral Particles - sc-105591-V from Santa Cruz Biotechnology
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Cytokeratin 75 RNAi - H00009119-R01 from Novus Biologicals
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MISSION® esiRNA - EHU025311 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11400 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11400 from Sigma-Aldrich
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KRT75 siRNA (Human) - CRH6026 from Cohesion Biosciences
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shRNA set against Human KRT75 (NM_004693.2) - SHH327669 from Creative biogene
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shRNA set against Human KRT75(NM_004693.2) - SHL206220 from Creative biogene
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Human KRT75 siRNA - orb266528 from Biorbyt
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KRT75 shRNA Plasmid (Human) - CHH6026 from Cohesion Biosciences
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KRT75 miRNA 3'UTR clone - MiUTR1H-05467 from Creative biogene
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