Gene Symbol | GCA |
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Entrez Gene | 25801 |
Alt Symbol | GCL |
Species | Human |
Gene Type | protein-coding |
Description | grancalcin, EF-hand calcium binding protein |
Other Description | grancalcin|grancalcin, EF-hand calcium-binding protein|grancalcin, penta-EF-hand protein |
Swissprots | Q59EP3 Q53TB5 P28676 B2R5X3 |
Accessions | AAX93138 EAX11350 EAX11351 P28676 AB209768 BAD93005 AK295413 BAH12058 AK312349 BAG35270 BC005214 AAH05214 BQ005142 HQ448365 ADQ32845 M81637 AAA58498 XM_005246446 XP_005246503 XM_006712398 XP_006712461 XM_006712399 XP_006712462 XM_006712400 XP_006712463 XM_006712401 XP_006712464 XM_011510926 XP_011509228 XM_011510927 XP_011509229 XM_011510928 XP_011509230 NM_012198 NP_036330 |
Function | Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions. |
Subcellular Location | Cytoplasm. Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic in the absence of calcium or magnesium ions. Relocates to granules and other membranes in response to elevated calcium and magnesium levels. |
Tissue Specificity | Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow. {ECO:0000269|PubMed:1737748}. |
Grancalcin CRISPR/Cas9 KO Plasmid (h) - sc-407953 from Santa Cruz Biotechnology
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Grancalcin HDR Plasmid (h) - sc-407953-HDR from Santa Cruz Biotechnology
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Grancalcin Double Nickase Plasmid (h) - sc-407953-NIC from Santa Cruz Biotechnology
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Grancalcin Double Nickase Plasmid (h2) - sc-407953-NIC-2 from Santa Cruz Biotechnology
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Grancalcin CRISPR Activation Plasmid (h) - sc-407953-ACT from Santa Cruz Biotechnology
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Grancalcin CRISPR Activation Plasmid (h2) - sc-407953-ACT-2 from Santa Cruz Biotechnology
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Grancalcin Lentiviral Activation Particles (h) - sc-407953-LAC from Santa Cruz Biotechnology
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Grancalcin Lentiviral Activation Particles (h2) - sc-407953-LAC-2 from Santa Cruz Biotechnology
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Grancalcin siRNA (h) - sc-43349 from Santa Cruz Biotechnology
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Grancalcin shRNA Plasmid (h) - sc-43349-SH from Santa Cruz Biotechnology
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Grancalcin shRNA (h) Lentiviral Particles - sc-43349-V from Santa Cruz Biotechnology
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Grancalcin RNAi - H00025801-R01 from Novus Biologicals
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MISSION® esiRNA - EHU009091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9178 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9178 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06858 from Sigma-Aldrich
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GCA siRNA (Human) - CRH8505 from Cohesion Biosciences
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GCA - MBS8233276 from MyBioSource
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shRNA set against Human GCA (NM_012198.3) - SHH299898 from Creative biogene
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Human GCA siRNA - orb269007 from Biorbyt
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GCA shRNA Plasmid (Human) - CHH8505 from Cohesion Biosciences
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GCA miRNA 3'UTR clone - MiUTR4H-TG03752 from Creative biogene
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