| Gene Symbol | Abcc1 |
|---|---|
| Entrez Gene | 17250 |
| Alt Symbol | Abcc1a, Abcc1b, MRP, Mdrap, Mrp1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
| Other Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 1a|ATP-binding cassette, sub-family C (CFTR/MRP), member 1b|LTC4 transporter|leukotriene C(4) transporter|multidrug resistance-associated protein 1|multiple drug resistance-associated protein |
| Swissprots | O35379 |
| Accessions | EDK97393 O35379 AF022908 AAB80938 AF213389 AAF31429 AI853854 AK029876 BAC26654 AK033750 AK045109 BAC32226 AK049174 BAC33586 AK051594 AK140421 AK150015 BAE29240 AK152781 AK162656 BC026509 BC090617 AAH90617 BP762240 XM_006521839 XP_006521902 NM_008576 NP_032602 |
| Function | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. {ECO:0000269|PubMed:9281595}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. |
| Top Pathways | ABC transporters, Vitamin digestion and absorption, MicroRNAs in cancer, Sphingolipid signaling pathway |