Gene Symbol | Abcc1 |
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Entrez Gene | 17250 |
Alt Symbol | Abcc1a, Abcc1b, MRP, Mdrap, Mrp1 |
Species | Mouse |
Gene Type | protein-coding |
Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
Other Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 1a|ATP-binding cassette, sub-family C (CFTR/MRP), member 1b|LTC4 transporter|leukotriene C(4) transporter|multidrug resistance-associated protein 1|multiple drug resistance-associated protein |
Swissprots | O35379 |
Accessions | EDK97393 O35379 AF022908 AAB80938 AF213389 AAF31429 AI853854 AK029876 BAC26654 AK033750 AK045109 BAC32226 AK049174 BAC33586 AK051594 AK140421 AK150015 BAE29240 AK152781 AK162656 BC026509 BC090617 AAH90617 BP762240 XM_006521839 XP_006521902 NM_008576 NP_032602 |
Function | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. {ECO:0000269|PubMed:9281595}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. |
Top Pathways | ABC transporters, Vitamin digestion and absorption, MicroRNAs in cancer, Sphingolipid signaling pathway |
MRP1 CRISPR/Cas9 KO Plasmid (m) - sc-421613 from Santa Cruz Biotechnology
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MRP1 HDR Plasmid (m) - sc-421613-HDR from Santa Cruz Biotechnology
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MRP1 Double Nickase Plasmid (m) - sc-421613-NIC from Santa Cruz Biotechnology
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MRP1 Double Nickase Plasmid (m2) - sc-421613-NIC-2 from Santa Cruz Biotechnology
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MRP1 CRISPR Activation Plasmid (m) - sc-421613-ACT from Santa Cruz Biotechnology
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MRP1 CRISPR Activation Plasmid (m2) - sc-421613-ACT-2 from Santa Cruz Biotechnology
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MRP1 Lentiviral Activation Particles (m) - sc-421613-LAC from Santa Cruz Biotechnology
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MRP1 Lentiviral Activation Particles (m2) - sc-421613-LAC-2 from Santa Cruz Biotechnology
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MRP1 siRNA (m) - sc-35961 from Santa Cruz Biotechnology
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MRP1 shRNA Plasmid (m) - sc-35961-SH from Santa Cruz Biotechnology
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MRP1 shRNA (m) Lentiviral Particles - sc-35961-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU053861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26045 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26045 from Sigma-Aldrich
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ABCC1 siRNA (Mouse) - CRM2505 from Cohesion Biosciences
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ABCC1 - MBS8205618 from MyBioSource
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shRNA set against Mouse ABCC1 (NM_008576.3) - SHH229074 from Creative biogene
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Mouse ABCC1 siRNA - orb281981 from Biorbyt
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ABCC1 shRNA Plasmid (Mouse) - CHM2505 from Cohesion Biosciences
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