| Gene Symbol |
SYNCRIP
|
| Entrez Gene |
10492
|
| Alt Symbol |
GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
synaptotagmin binding, cytoplasmic RNA interacting protein
|
| Other Description |
NS1-associated protein 1|glycine- and tyrosine-rich RNA-binding protein|heterogeneous nuclear ribonucleoprotein Q
|
| Swissprots |
Q96LC2 E1P502 Q5TCG2 Q8N599 Q9Y583 Q5TCG3 Q53H05 Q96LC1 O60506 E1P501 Q8IW78
|
| Accessions |
EAW48622 EAW48623 EAW48624 EAW48625 EAW48626 EAW48627 EAW48628 EAW48629 EAW48630 O60506 AA411631 AB209098 BAD92335 AF037448 AAC12926 AF155568 AAD38198 AK056188 AK222776 BAD96496 AK294212 BAH11699 AK299796 BAH13131 AK313572 BAG36345 AY034481 AAK59703 AY034482 AAK59704 AY034483 AAK59705 BC009176 BC015575 AAH15575 BC021932 BC024283 AAH24283 BC032643 AAH32643 BC040844 AAH40844 BF221524 CV806885 DA117533 DA845413 DB160837 JF432810 ADZ16027 XM_005248635 XP_005248692 XM_005248636 XP_005248693 XM_005248637 XP_005248694 NM_001159673 NP_001153145 NM_001159674 NP_001153146 NM_001159675 NP_001153147 NM_001159676 NP_001153148 NM_001159677 NP_001153149 NM_001253771 NP_001240700 NM_006372 NP_006363
|
| Function |
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with s
|
| Subcellular Location |
Isoform 2: Nucleus, nucleoplasm {ECO:0000250}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis. {ECO:0000269|PubMed:11352648}.
|
