Gene Symbol | KRT73 |
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Entrez Gene | 319101 |
Alt Symbol | IRT6IRS3, K6IRS3, KRT6IRS3 |
Species | Human |
Gene Type | protein-coding |
Description | keratin 73, type II |
Other Description | CK-73|K73|cytokeratin-73|keratin 6 irs3|keratin, type II cytoskeletal 73|keratin-73|type II inner root sheath-specific keratin-K6irs3|type-II keratin Kb36 |
Swissprots | Q32MB2 Q86Y46 |
Accessions | EAW96640 Q86Y46 AJ508776 CAD48513 BC109212 AAI09213 XM_011538257 XP_011536559 XM_011538258 XP_011536560 NM_175068 NP_778238 |
Function | Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}. |
Tissue Specificity | Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level). {ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310}. |
Keratin 73 CRISPR/Cas9 KO Plasmid (h) - sc-415473 from Santa Cruz Biotechnology
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Keratin 73 HDR Plasmid (h) - sc-415473-HDR from Santa Cruz Biotechnology
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Keratin 73 Double Nickase Plasmid (h) - sc-415473-NIC from Santa Cruz Biotechnology
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Keratin 73 Double Nickase Plasmid (h2) - sc-415473-NIC-2 from Santa Cruz Biotechnology
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Keratin 73 CRISPR Activation Plasmid (h) - sc-415473-ACT from Santa Cruz Biotechnology
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Keratin 73 CRISPR Activation Plasmid (h2) - sc-415473-ACT-2 from Santa Cruz Biotechnology
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Keratin 73 Lentiviral Activation Particles (h) - sc-415473-LAC from Santa Cruz Biotechnology
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Keratin 73 Lentiviral Activation Particles (h2) - sc-415473-LAC-2 from Santa Cruz Biotechnology
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Keratin 73 siRNA (h) - sc-95821 from Santa Cruz Biotechnology
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Keratin 73 shRNA Plasmid (h) - sc-95821-SH from Santa Cruz Biotechnology
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Keratin 73 shRNA (h) Lentiviral Particles - sc-95821-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN11398 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11398 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05466 from Sigma-Aldrich
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KRT73 siRNA (Human) - CRJ7198 from Cohesion Biosciences
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shRNA set against Human KRT73 (NM_175068.2) - SHH327647 from Creative biogene
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shRNA set against Human KRT73(NM_175068.2) - SHL199080 from Creative biogene
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Human KRT73 siRNA - orb277699 from Biorbyt
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KRT73 shRNA Plasmid (Human) - CHJ7198 from Cohesion Biosciences
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KRT73 miRNA 3'UTR clone - MiUTR1H-05465 from Creative biogene
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