Gene Symbol | PKLR |
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Entrez Gene | 5313 |
Alt Symbol | PK1, PKL, PKR, PKRL, RPK |
Species | Human |
Gene Type | protein-coding |
Description | pyruvate kinase, liver and RBC |
Other Description | R-type/L-type pyruvate kinase|pyruvate kinase 1|pyruvate kinase PKLR|pyruvate kinase isozyme R/L|pyruvate kinase isozymes L/R|pyruvate kinase isozymes R/L|pyruvate kinase type L|pyruvate kinase, liver and blood cell|red cell/liver pyruvate kinase |
Swissprots | P11973 P30613 O75758 |
Accessions | AAA92535 AAA92536 AAP69527 BAA02515 EAW53079 EAW53080 P30613 AB015983 BAA31706 AK225947 AK298399 BAG60632 BC025737 AAH25737 BF110802 EU176228 ABW03679 M15465 AAA60104 S60712 AAB26262 XM_005245266 XP_005245323 XM_006711386 XP_006711449 XM_006726212 XP_006726275 XM_011509639 XP_011507941 XM_011509640 XP_011507942 XM_011546931 XP_011545233 XM_011546932 XP_011545234 NM_000298 NP_000289 NM_181871 NP_870986 |
Function | Plays a key role in glycolysis. {ECO:0000250}. |
Top Pathways | Maturity onset diabetes of the young, Type II diabetes mellitus, Insulin signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Glycolysis / Gluconeogenesis |
PKLR CRISPR/Cas9 KO Plasmid (h) - sc-402315 from Santa Cruz Biotechnology
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PKLR HDR Plasmid (h) - sc-402315-HDR from Santa Cruz Biotechnology
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PKLR Double Nickase Plasmid (h) - sc-402315-NIC from Santa Cruz Biotechnology
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PKLR Double Nickase Plasmid (h2) - sc-402315-NIC-2 from Santa Cruz Biotechnology
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PKLR CRISPR Activation Plasmid (h) - sc-402315-ACT from Santa Cruz Biotechnology
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PKLR CRISPR Activation Plasmid (h2) - sc-402315-ACT-2 from Santa Cruz Biotechnology
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PKLR Lentiviral Activation Particles (h) - sc-402315-LAC from Santa Cruz Biotechnology
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PKLR Lentiviral Activation Particles (h2) - sc-402315-LAC-2 from Santa Cruz Biotechnology
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PKLR siRNA (h) - sc-62818 from Santa Cruz Biotechnology
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PKLR shRNA Plasmid (h) - sc-62818-SH from Santa Cruz Biotechnology
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PKLR shRNA (h) Lentiviral Particles - sc-62818-V from Santa Cruz Biotechnology
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PKLR RNAi - H00005313-R05 from Novus Biologicals
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PKLR RNAi - H00005313-R06 from Novus Biologicals
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MISSION® esiRNA - EHU064181 from Sigma-Aldrich
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MISSION® siRNA - SIHK1723 from Sigma-Aldrich
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MISSION® siRNA - SIHK1725 from Sigma-Aldrich
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MISSION® siRNA - SIHK1724 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16868 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16868 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06059 from Sigma-Aldrich
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PKLR siRNA (Human) - CRH3554 from Cohesion Biosciences
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shRNA set against Human PKLR (NM_000298.5) - SHH376504 from Creative biogene
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Human PKLR siRNA - orb264056 from Biorbyt
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PKLR shRNA Plasmid (Human) - CHH3554 from Cohesion Biosciences
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PKLR miRNA 3'UTR clone - MiUTR3H-10762 from Creative biogene
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