CHMP2A

Gene Symbol CHMP2A
Entrez Gene 27243
Alt Symbol BC-2, BC2, CHMP2, VPS2, VPS2A
Species Human
Gene Type protein-coding
Description charged multivesicular body protein 2A
Other Description VPS2 homolog A|charged multivesicular body protein 2a|chromatin modifying protein 2A|putative breast adenocarcinoma marker (32kD)|putative breast adenocarcinoma marker BC-2|vacuolar protein sorting-associated protein 2-1|vps2-1
Swissprots Q3ZTT0 B2R4W6 O43633
Accessions CAC14310 EAW72608 EAW72609 EAW72610 EAW72611 O43633 AF042384 AAC00005 AK092868 AK311974 BAG34913 AY364248 AAQ76807 BC002502 AAH02502 BC047005 BE856471 BG546479 BI457978 BP315111 BT007298 AAP35962 BU147101 CN305066 CR457002 CAG33283 DQ892587 ABM83513 DQ895805 ABM86731 XM_005258746 XP_005258803 XM_005258747 XP_005258804 NM_014453 NP_055268 NM_198426 NP_940818
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location Late endosome membrane {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Peripheral membrane protein {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Cytoplasmic side {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Top Pathways Endocytosis

CHMP2 (C-17) - sc-49905 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CHMP2 (C-17): sc-49905. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic and nuclear staining of glandular cells.

CHMP2 (N-13) - sc-49907 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CHMP2 (P-13) - sc-49908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CHMP2 (P-13): sc-49908. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic and nuclear staining of glandular cells.

CHMP2A (H-105) - sc-67227 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CHMP2A (H-105): sc-67227. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic and membrane staining of glandular cells.

Anti-CHMP2A antibody - ab76335 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CHMP2A antibody - ab67064 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CHMP2A antibody (ab67064) at 1/500 dilutionLane 1 : CHMP2A transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Anti-CHMP2A antibody - ab118729 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CHMP2A antibody (ab118729) at 1 µg/ml + 293T cell lysate at 10 µg

Anti-CHMP2A Antibody (Biotin) - LS-C211716 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHMP2A Antibody (FITC) - LS-C211715 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHMP2A Antibody (HRP) - LS-C211714 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CHMP2A Antibody - LS-C306946 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CHMP2A Antibody (C-Terminus) - LS-C145722 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CHMP2A antibody LS-C145722 Western blot of 293T Cell lysate. Antibody concentration 1 ug/ml.

Anti-CHMP2A Antibody (N-Terminus) - LS-C146294 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CHMP2A antibody LS-C146294 Western blot of Fetal Lung lysate. Antibody concentration 1 ug/ml.

Anti-CHMP2A Antibody IHC-plus™ - LS-B11387 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CHMP2A antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11387 concentration 20 ug/ml.

CHMP2A Antibody - NBP1-03385 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CHMP2A Antibody - NBP1-91781 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: CHMP2A Antibody [NBP1-91781] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells.

CHMP2A Antibody - NBP1-91780 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: CHMP2A Antibody [NBP1-91780] - Staining of human urinary bladder shows strong cytoplasmic positivity in urothelium.

CHMP2A Antibody - H00027243-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: CHMP2A Antibody [H00027243-B01P] - Analysis of CHMP2A expression in transfected 293T cell line by CHMP2A polyclonal antibody. Lane 1: CHMP2A transfected lysate(24.42 KDa). Lane 2: Non-transfected lysate.

CHMP2A Polyclonal Antibody - bs-13913R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat stomach tissue labeled with Rabbit Anti-CHMP2A Polyclonal Antibody, Unconjugated (bs-13913R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-CHMP2A antibody produced in rabbit - HPA042031 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CHMP2A: <B>Cat. No. HPA042031</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.

Anti-CHMP2A antibody produced in mouse - SAB1407347 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CHMP2A: <B>Cat. No. SAB1407347</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~24.4 kDa using CHMP2A transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-CHMP2A antibody produced in rabbit - SAB2107678 from Sigma-Aldrich

Prices $341.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CHMP2A: <B>Cat. No. SAB2107678</B>: Western blot analysis of CHMP2A in 293T with CHMP2A (chromatin modifying protein 2A) antibody against the C terminal of CHMP2A (50 μg) antibody at 1.0 μg/mL.

CHMP2A antibody - N-terminal region (ARP62111_P050) - ARP62111_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CHMP2A antibody - C-terminal region (ARP62112_P050) - ARP62112_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CHMP2A antibody - GTX102142 from GeneTex

Prices $149.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
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