CHMP2A

Gene Symbol	CHMP2A
Entrez Gene	27243
Alt Symbol	BC-2, BC2, CHMP2, VPS2, VPS2A
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 2A
Other Description	VPS2 homolog A|charged multivesicular body protein 2a|chromatin modifying protein 2A|putative breast adenocarcinoma marker (32kD)|putative breast adenocarcinoma marker BC-2|vacuolar protein sorting-associated protein 2-1|vps2-1
Swissprots	Q3ZTT0 B2R4W6 O43633
Accessions	CAC14310 EAW72608 EAW72609 EAW72610 EAW72611 O43633 AF042384 AAC00005 AK092868 AK311974 BAG34913 AY364248 AAQ76807 BC002502 AAH02502 BC047005 BE856471 BG546479 BI457978 BP315111 BT007298 AAP35962 BU147101 CN305066 CR457002 CAG33283 DQ892587 ABM83513 DQ895805 ABM86731 XM_005258746 XP_005258803 XM_005258747 XP_005258804 NM_014453 NP_055268 NM_198426 NP_940818
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Late endosome membrane {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Peripheral membrane protein {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}; Cytoplasmic side {ECO:0000269|PubMed:16730941, ECO:0000269|PubMed:17853893}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CHMP2A full length protein - ab87754 from Abcam Category Protein Source E. coli Species Human

CHMP2A Antibody Blocking Peptide - LS-E22685 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP2A Recombinant Protein - H00027243-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CHMP2A Protein - NBP1-30206 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

CHMP2A Protein (OPPA01396) - OPPA01396 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human BC2 protein - orb245212 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Chromatin Modifying Protein 2A protein - orb81031 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

CHMP2A protein (His tag) - 80R-1186 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

CHMP2A / BC2 (1-222, His-tag) - AR09253PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

CHMP2A / BC2 (1-222, His-tag) - AR09253PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

CHMP2A / BC2 - H00027243-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CHMP2A / BC2 - H00027243-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CHMP2A, 1-222 aa, Human, His-tagged, Recombinant, E.coli - 01-2146 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Source E.coli Species Human

CHMP2A fusion protein - Ag0719 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Chromatin Modifying Protein 2A - BP001884-PRO-503 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

CHMP2A, 1-222 aa, Recombinant Protein - GWB-P1668D from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Chromatin Modifying Protein 2A, His-tagged - CHMP2A-1396H from Creative Biomart Category Protein Source E.coli .

Recombinant Human CHMP2A, His-tagged - CHMP2A-26719TH from Creative Biomart Category Protein Source E. coli

Recombinant Human CHMP2A, His-tagged - CHMP2A-27958TH from Creative Biomart Category Protein Source E. coli

Recombinant Human CHMP2A, GST-tagged - CHMP2A-11184H from Creative Biomart Category Protein Source E.coli Species Human

CHMP2A 1-222 aa - CMB-203 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

CHMP2A Human - NKX-807 from Reagent Proteins Category Protein Prices $364.00, $3,766.00 Sizes 1 mg, 20.00 µg Source E.coli Species Human

CHMP2A - PAT-80358-1 from Nordic BioSite Category Protein Species Human

Recombinant human Charged multivesicular body protein 2a protein - CSB-EP045244h CSB-BP045244h CSB-MP045244h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Charged multivesicular body protein 2a(CHMP2A) - CSB-RP045244h from Cusabio Category Protein Source E.coli Species Human

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