| Gene Symbol |
ACTR3
|
| Entrez Gene |
10096
|
| Alt Symbol |
ARP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ARP3 actin-related protein 3 homolog (yeast)
|
| Other Description |
actin-like protein 3|actin-related protein 3
|
| Swissprots |
Q53QM2 P61158
|
| Accessions |
AAX93226 EAW95179 EAW95180 EAW95181 EAW95182 P61158 AB209353 BAD92590 AF006083 AAB64188 AF127773 AAD51904 AI521063 AK300030 BAG61841 AK300224 BAG61992 AK302152 BAG63523 AK302359 BAG63684 AK303988 BAG64905 AK312659 BAG35542 AK316213 BAH14584 AK316396 BAH14767 AL832773 BC044590 AAH44590 DB453995 NM_001277140 NP_001264069 NM_005721 NP_005712 NR_102318
|
| Function |
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:9000076}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).
|
![Western Blot: ACTR3 Overexpression Lysate (Adult Normal) [NBL1-07288] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ACTR3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/18496_ACTR3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07288-img0002.jpg)