Gene Symbol | ACTR3 |
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Entrez Gene | 10096 |
Alt Symbol | ARP3 |
Species | Human |
Gene Type | protein-coding |
Description | ARP3 actin-related protein 3 homolog (yeast) |
Other Description | actin-like protein 3|actin-related protein 3 |
Swissprots | Q53QM2 P61158 |
Accessions | AAX93226 EAW95179 EAW95180 EAW95181 EAW95182 P61158 AB209353 BAD92590 AF006083 AAB64188 AF127773 AAD51904 AI521063 AK300030 BAG61841 AK300224 BAG61992 AK302152 BAG63523 AK302359 BAG63684 AK303988 BAG64905 AK312659 BAG35542 AK316213 BAH14584 AK316396 BAH14767 AL832773 BC044590 AAH44590 DB453995 NM_001277140 NP_001264069 NM_005721 NP_005712 NR_102318 |
Function | Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:9000076}. |
Subcellular Location | Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). |
Arp3 CRISPR/Cas9 KO Plasmid (h) - sc-401874 from Santa Cruz Biotechnology
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Arp3 HDR Plasmid (h) - sc-401874-HDR from Santa Cruz Biotechnology
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Arp3 Double Nickase Plasmid (h) - sc-401874-NIC from Santa Cruz Biotechnology
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Arp3 Double Nickase Plasmid (h2) - sc-401874-NIC-2 from Santa Cruz Biotechnology
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Arp3 CRISPR Activation Plasmid (h) - sc-401874-ACT from Santa Cruz Biotechnology
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Arp3 CRISPR Activation Plasmid (h2) - sc-401874-ACT-2 from Santa Cruz Biotechnology
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Arp3 Lentiviral Activation Particles (h) - sc-401874-LAC from Santa Cruz Biotechnology
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Arp3 Lentiviral Activation Particles (h2) - sc-401874-LAC-2 from Santa Cruz Biotechnology
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Arp3 siRNA (h) - sc-29739 from Santa Cruz Biotechnology
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Arp3 shRNA Plasmid (h) - sc-29739-SH from Santa Cruz Biotechnology
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Arp3 shRNA (h) Lentiviral Particles - sc-29739-V from Santa Cruz Biotechnology
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ACTR3 RNAi - H00010096-R01 from Novus Biologicals
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MISSION® esiRNA - EHU108371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2787 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2787 from Sigma-Aldrich
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ACTR3 siRNA (Human) - CRH6804 from Cohesion Biosciences
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ACTR3 - MBS8226726 from MyBioSource
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shRNA set against Human ACTR3 (NM_005721.3) - SHH231126 from Creative biogene
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shRNA set against Human ACTR3(NM_005721.3) - SHG037007 from Creative biogene
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ACTR3 shRNA Plasmid (Human) - CHH6804 from Cohesion Biosciences
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ACTR3 miRNA 3'UTR clone - MiUTR1H-00140 from Creative biogene
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