| Gene Symbol |
UBAP1
|
| Entrez Gene |
51271
|
| Alt Symbol |
NAG20, UAP, UBAP, UBAP-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin associated protein 1
|
| Other Description |
nasopharyngeal carcinoma-associated gene 20 protein|ubiquitin-associated protein 1
|
| Swissprots |
Q8NCH9 F5GXE2 Q6FI75 Q5T7B3 B7Z348 B7Z8N9 Q8NC52 F5H0J8 D3DRL7 Q4V759 Q9NZ09 Q53FP7 Q8NCG6
|
| Accessions |
CAF86203 CAF86817 EAW58467 EAW58468 EAW58469 EAW58470 Q9NZ09 AF222043 AAF37827 AK074426 AK074724 BAC11162 AK074745 BAC11176 AK074812 BAC11224 AK074969 BAC11323 AK074995 BAC11342 AK223235 BAD96955 AK295482 BAH12084 AK303711 BAH14025 AK309329 AL136733 CAB66667 AM393865 CAL38740 BC020950 AAH20950 BC098141 AAH98141 BC098316 AAH98316 BC099726 AAH99726 BC100668 AAI00669 BF527586 BP237024 BX473128 CR533551 CAG38582 DA741347 DQ891690 ABM82616 DQ894873 ABM85799 XM_006716779 XP_006716842 XM_011517898 XP_011516200 XM_011517899 XP_011516201 XM_011517900 XP_011516202 NM_001171201 NP_001164672 NM_001171202 NP_001164673 NM_001171203 NP_001164674 NM_001171204 NP_001164675 NM_016525 NP_057609 NR_033243
|
| Function |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2. {ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22405001}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:21757351}. Endosome {ECO:0000269|PubMed:21757351}. Note=Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:11599797}.
|