Gene Symbol | ACSM1 |
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Entrez Gene | 116285 |
Alt Symbol | BUCS1, MACS1 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA synthetase medium-chain family member 1 |
Other Description | Butyrate CoA ligase|acyl-coenzyme A synthetase ACSM1, mitochondrial|butyrate--CoA ligase 1|butyryl Coenzyme A synthetase 1|butyryl-coenzyme A synthetase 1|lipoate-activating enzyme|medium-chain acyl-CoA synthetase|middle-chain acyl-CoA synthetase 1 |
Swissprots | Q08AH1 Q96A20 Q08AH2 |
Accessions | AAC23498 BAB68363 EAW66826 EAW66827 EAW66828 Q08AH1 AB059429 BAB64535 AK092574 AK314282 BAG36941 BC125177 AAI25178 BC125178 AAI25179 XM_005255084 XP_005255141 XM_006721016 XP_006721079 XM_006721017 XP_006721080 XM_006721018 XP_006721081 XM_011545729 XP_011544031 XM_011545730 XP_011544032 XM_011545731 XP_011544033 XM_011545732 XP_011544034 XR_243258 XR_429672 XR_950737 XR_950738 XR_950740 NM_052956 NP_443188 |
Function | Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Functions as GTP-dependent lipoate- activating enzyme that generates the substrate for lipoyltransferase (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion matrix {ECO:0000250}. |
Top Pathways | Butanoate metabolism |
MACS1 CRISPR/Cas9 KO Plasmid (h) - sc-410260 from Santa Cruz Biotechnology
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MACS1 HDR Plasmid (h) - sc-410260-HDR from Santa Cruz Biotechnology
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MACS1 Double Nickase Plasmid (h) - sc-410260-NIC from Santa Cruz Biotechnology
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MACS1 Double Nickase Plasmid (h2) - sc-410260-NIC-2 from Santa Cruz Biotechnology
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MACS1 CRISPR Activation Plasmid (h) - sc-410260-ACT from Santa Cruz Biotechnology
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MACS1 CRISPR Activation Plasmid (h2) - sc-410260-ACT-2 from Santa Cruz Biotechnology
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MACS1 Lentiviral Activation Particles (h) - sc-410260-LAC from Santa Cruz Biotechnology
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MACS1 Lentiviral Activation Particles (h2) - sc-410260-LAC-2 from Santa Cruz Biotechnology
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MACS1 siRNA (h) - sc-93228 from Santa Cruz Biotechnology
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MACS1 shRNA Plasmid (h) - sc-93228-SH from Santa Cruz Biotechnology
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MACS1 shRNA (h) Lentiviral Particles - sc-93228-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU124371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2757 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2757 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01463 from Sigma-Aldrich
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ACSM1 siRNA (Human) - CRJ4505 from Cohesion Biosciences
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ACSM1 - MBS8220519 from MyBioSource
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shRNA set against Human ACSM1 (NM_052956.2) - SHH230782 from Creative biogene
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Human ACSM1 siRNA - orb275006 from Biorbyt
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ACSM1 shRNA Plasmid (Human) - CHJ4505 from Cohesion Biosciences
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ACSM1 miRNA 3'UTR clone - MiUTR1H-00127 from Creative biogene
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