| Gene Symbol |
NEK4
|
| Entrez Gene |
6787
|
| Alt Symbol |
NRK2, STK2, pp12301
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NIMA-related kinase 4
|
| Other Description |
NIMA (never in mitosis gene a)-related kinase 4|never in mitosis A-related kinase 4|nimA-related protein kinase 4|serine/threonine kinase 2|serine/threonine protein kinase-2|serine/threonine-protein kinase 2|serine/threonine-protein kinase NRK2|serine/threonine-protein kinase Nek4|serine/threonine-protein kinase Nek4 variant 2
|
| Swissprots |
Q6P576 P51957 B2R633 A5YM70 B7Z200
|
| Accessions |
EAW65258 P51957 AI860526 AK294165 BAH11686 AK312420 BAG35330 BC015515 AAH15515 BC063044 AAH63044 DB073127 EF560744 ABQ59054 KJ592714 AHZ86932 L20321 AAA36658 XM_006713310 XP_006713373 XM_011534039 XP_011532341 XM_011534040 XP_011532342 NM_001193533 NP_001180462 NM_003157 NP_003148
|
| Function |
Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.
|
| Subcellular Location |
Cell projection, cilium {ECO:0000269|PubMed:21685204}. Cytoplasm {ECO:0000269|PubMed:21685204}.
|
| Tissue Specificity |
Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. {ECO:0000269|PubMed:21685204, ECO:0000269|PubMed:8208544}.
|