NEK4
| Gene Symbol | NEK4 |
|---|---|
| Entrez Gene | 6787 |
| Alt Symbol | NRK2, STK2, pp12301 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NIMA-related kinase 4 |
| Other Description | NIMA (never in mitosis gene a)-related kinase 4|never in mitosis A-related kinase 4|nimA-related protein kinase 4|serine/threonine kinase 2|serine/threonine protein kinase-2|serine/threonine-protein kinase 2|serine/threonine-protein kinase NRK2|serine/threonine-protein kinase Nek4|serine/threonine-protein kinase Nek4 variant 2 |
| Swissprots | Q6P576 P51957 B2R633 A5YM70 B7Z200 |
| Accessions | EAW65258 P51957 AI860526 AK294165 BAH11686 AK312420 BAG35330 BC015515 AAH15515 BC063044 AAH63044 DB073127 EF560744 ABQ59054 KJ592714 AHZ86932 L20321 AAA36658 XM_006713310 XP_006713373 XM_011534039 XP_011532341 XM_011534040 XP_011532342 NM_001193533 NP_001180462 NM_003157 NP_003148 |
| Function | Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}. |
| Subcellular Location | Cell projection, cilium {ECO:0000269|PubMed:21685204}. Cytoplasm {ECO:0000269|PubMed:21685204}. |
| Tissue Specificity | Highest expression in adult heart, followed by pancreas, skeletal muscle, brain, testis, retina, liver, kidney, lung and placenta. Present in most primary carcinomas. {ECO:0000269|PubMed:21685204, ECO:0000269|PubMed:8208544}. |
Nek4 (C-17) - sc-5517 from Santa Cruz Biotechnology
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Nek4 (H-31) - sc-292488 from Santa Cruz Biotechnology
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Nek4 (M-17) - sc-9370 from Santa Cruz Biotechnology
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Nek4 (2631C1a) - sc-81332 from Santa Cruz Biotechnology
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Anti-NEK4 antibody - ab95176 from Abcam
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Anti-NEK4 antibody - ab198723 from Abcam
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Anti-NEK4 antibody - ab96607 from Abcam
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Anti-NEK4 antibody - ab95189 from Abcam
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Anti-NEK4 antibody - ab57835 from Abcam
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Anti-NEK4 antibody [EPR8462] - ab150438 from Abcam
![All lanes : Anti-NEK4 antibody [EPR8462] (ab150438) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : Y79 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP labelled antibody at 1/2000 dilution](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_3/28895_NEK4-Primary-antibodies-ab150438-1.jpg)
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Anti-NEK4 antibody - N-terminal - ab172863 from Abcam
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Anti-NEK4 Antibody - LS-C73255 from LifeSpan Bioscience
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Anti-NEK4 Antibody (clone 2631C1a) - LS-C184585 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa74-101, AP) - LS-C264195 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa74-101, APC) - LS-C264196 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa74-101, Biotin) - LS-C264198 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa74-101, FITC) - LS-C264199 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa74-101, Azide-free, HRP) - LS-C264200 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa74-101, PE) - LS-C264201 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa73-101) - LS-C323287 from LifeSpan Bioscience
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Anti-NEK4 Antibody (clone 1B8) - LS-C198282 from LifeSpan Bioscience
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Anti-NEK4 Antibody (clone 2631C1a) - LS-C342618 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa475-525) - LS-C289393 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa350-400) - LS-C289392 from LifeSpan Bioscience
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Anti-NEK4 Antibody (aa74-101) - LS-C164496 from LifeSpan Bioscience
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