| Gene Symbol |
Acsl4
|
| Entrez Gene |
50790
|
| Alt Symbol |
9430020A05Rik, ACS4, AU018108, Facl4, Lacs4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
acyl-CoA synthetase long-chain family member 4
|
| Other Description |
LACS 4|fatty acid-Coenzyme A ligase, long chain 4|long-chain acyl-CoA synthetase 4|long-chain-fatty-acid--CoA ligase 4|mACS4
|
| Swissprots |
Q5D071 Q9QUJ7 Q9R0H3 Q9JHT4
|
| Accessions |
CBF65116 CBU89987 EDL14748 EDL14749 EDL14750 Q9QUJ7 AB033885 BAA85929 AB033886 BAA85930 AB033887 BAA85931 AJ243502 CAB95965 AK034650 AK054387 BAC35758 AK165950 AK181492 BB857663 BC016416 AAH16416 BC058663 AAH58663 XM_011247842 XP_011246144 XM_011247843 XP_011246145 NM_001033600 NP_001028772 NM_019477 NP_062350 NM_207625 NP_997508
|
| Function |
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Abundant in steroidogenic tissues, also found in the kidney, brain and liver.
|
| Top Pathways |
Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation
|