| Gene Symbol | Acsl4 |
|---|---|
| Entrez Gene | 50790 |
| Alt Symbol | 9430020A05Rik, ACS4, AU018108, Facl4, Lacs4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | acyl-CoA synthetase long-chain family member 4 |
| Other Description | LACS 4|fatty acid-Coenzyme A ligase, long chain 4|long-chain acyl-CoA synthetase 4|long-chain-fatty-acid--CoA ligase 4|mACS4 |
| Swissprots | Q5D071 Q9QUJ7 Q9R0H3 Q9JHT4 |
| Accessions | CBF65116 CBU89987 EDL14748 EDL14749 EDL14750 Q9QUJ7 AB033885 BAA85929 AB033886 BAA85930 AB033887 BAA85931 AJ243502 CAB95965 AK034650 AK054387 BAC35758 AK165950 AK181492 BB857663 BC016416 AAH16416 BC058663 AAH58663 XM_011247842 XP_011246144 XM_011247843 XP_011246145 NM_001033600 NP_001028772 NM_019477 NP_062350 NM_207625 NP_997508 |
| Function | Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. |
| Tissue Specificity | Abundant in steroidogenic tissues, also found in the kidney, brain and liver. |
| Top Pathways | Adipocytokine signaling pathway, PPAR signaling pathway, Peroxisome, Fatty acid biosynthesis, Fatty acid degradation |
ACSL4 CRISPR/Cas9 KO Plasmid (m) - sc-424503 from Santa Cruz Biotechnology
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ACSL4 HDR Plasmid (m) - sc-424503-HDR from Santa Cruz Biotechnology
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ACSL4 Double Nickase Plasmid (m) - sc-424503-NIC from Santa Cruz Biotechnology
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ACSL4 Double Nickase Plasmid (m2) - sc-424503-NIC-2 from Santa Cruz Biotechnology
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ACSL4 CRISPR Activation Plasmid (m) - sc-424503-ACT from Santa Cruz Biotechnology
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ACSL4 CRISPR Activation Plasmid (m2) - sc-424503-ACT-2 from Santa Cruz Biotechnology
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ACSL4 Lentiviral Activation Particles (m) - sc-424503-LAC from Santa Cruz Biotechnology
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ACSL4 Lentiviral Activation Particles (m2) - sc-424503-LAC-2 from Santa Cruz Biotechnology
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ACSL4 siRNA (m) - sc-60620 from Santa Cruz Biotechnology
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ACSL4 shRNA Plasmid (m) - sc-60620-SH from Santa Cruz Biotechnology
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ACSL4 shRNA (m) Lentiviral Particles - sc-60620-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU084681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN26190 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26190 from Sigma-Aldrich
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ACSL4 siRNA (Mouse) - CRM5155 from Cohesion Biosciences
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ACSL4 - MBS8219381 from MyBioSource
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shRNA set against Mouse ACSL4 (NM_019477.3) - SHH230750 from Creative biogene
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shRNA set against Mouse Acsl4(NM_019477.3) - SHG035785 from Creative biogene
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shRNA set against Mouse Acsl4(NM_001033600.1) - SHG035845 from Creative biogene
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shRNA set against Mouse Acsl4(NM_207625.2) - SHG035863 from Creative biogene
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shRNA set against Mouse Acsl4(NM_019477.3) - SHG035881 from Creative biogene
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Mouse ACSL4 siRNA - orb284631 from Biorbyt
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ACSL4 shRNA Plasmid (Mouse) - CHM5155 from Cohesion Biosciences
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ACSL4 miRNA 3'UTR clone - MiUTR1M-01134 from Creative biogene
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