Gene Symbol | RMDN3 |
---|---|
Entrez Gene | 55177 |
Alt Symbol | FAM82A2, FAM82C, RMD-3, RMD3, ptpip51 |
Species | Human |
Gene Type | protein-coding |
Description | regulator of microtubule dynamics 3 |
Other Description | TCPTP-interacting protein 51|cerebral protein 10|family with sequence similarity 82, member A2|family with sequence similarity 82, member C|microtubule-associated protein|protein tyrosine phosphatase-interacting protein 51|regulator of microtubule dynamics protein 3 |
Swissprots | Q96SD6 Q96H23 A9UMZ9 Q96TC7 Q9H6G1 Q6ZWE9 B3KRR3 Q9NVQ6 |
Accessions | CAC33289 CAC38596 CAC39480 CAE89415 EAW92436 EAW92437 EAW92438 EAW92439 EAW92440 EAW92441 Q96TC7 AA772280 AB000782 BAB46923 AK001441 BAA91693 AK025963 BAB15298 AK090731 AK092058 BAG52475 AK097286 BAG53446 AK123192 BAC85554 AK123282 BAG53885 AY358793 AAQ89153 BC008970 AAH08970 BC063844 AAH63844 BR000691 FAA00416 DA280017 DA592879 HQ447480 ADQ31966 XM_005254531 XP_005254588 XM_011521755 XP_011520057 NM_001304802 NP_001291731 NM_018145 NP_060615 |
Function | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
Subcellular Location | Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. |
Tissue Specificity | Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed. {ECO:0000269|PubMed:15609043, ECO:0000269|PubMed:16820967}. |
PTPIP51 (E-14) - sc-160690 from Santa Cruz Biotechnology
|
||||||||
Anti-FAM82A2 antibody - ab100802 from Abcam
|
||||||||
Anti-FAM82A2 antibody - ab100803 from Abcam
|
||||||||
Anti-FAM82A2 antibody - ab69337 from Abcam
|
||||||||
Anti-FAM82A2 antibody - C-terminal - ab189845 from Abcam
|
||||||||
Anti-RMDN3 Antibody (aa420-470) - LS-C289540 from LifeSpan Bioscience
|
||||||||
Anti-RMDN3 Antibody - LS-C307472 from LifeSpan Bioscience
|
||||||||
Anti-RMDN3 Antibody (aa395-444) - LS-C111139 from LifeSpan Bioscience
|
||||||||
Anti-RMDN3 Antibody (aa23-72) - LS-C201530 from LifeSpan Bioscience
|
||||||||
Anti-RMDN3 Antibody - LS-C335604 from LifeSpan Bioscience
|
||||||||
Anti-RMDN3 Antibody (aa300-350) - LS-C289539 from LifeSpan Bioscience
|
||||||||
PTPIP51 Antibody - NBP1-84738 from Novus Biologicals
|
||||||||
PTPIP51 Antibody - NBP1-47293 from Novus Biologicals
|
||||||||
PTPIP51 Antibody - NBP1-62474 from Novus Biologicals
|
||||||||
PTPIP51 Antibody - H00055177-B01P from Novus Biologicals
|
||||||||
PTPIP51 Antibody - NBP1-47294 from Novus Biologicals
|
||||||||
PTPIP51 Polyclonal Antibody - bs-5719R from Bioss
|
||||||||
Anti-FAM82C antibody produced in rabbit - SAB2103199 from Sigma-Aldrich
|
||||||||
Anti-FAM82C antibody produced in mouse - SAB1407628 from Sigma-Aldrich
|
||||||||
Anti-RMDN3 antibody produced in rabbit - SAB4301169 from Sigma-Aldrich
|
||||||||
Anti-RMDN3 antibody produced in rabbit - HPA009975 from Sigma-Aldrich
|
||||||||
RMDN3 Antibody - N-terminal region (ARP47399_P050) - ARP47399_P050 from Aviva Systems Biology
|
||||||||
FAM82C antibody - middle region (ARP47400_P050) - ARP47400_P050 from Aviva Systems Biology
|
||||||||
FAM82C antibody, Internal - GTX46304 from GeneTex
|
||||||||
FAM82C antibody - 70R-7324 from Fitzgerald
|