Gene Symbol | RMDN3 |
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Entrez Gene | 55177 |
Alt Symbol | FAM82A2, FAM82C, RMD-3, RMD3, ptpip51 |
Species | Human |
Gene Type | protein-coding |
Description | regulator of microtubule dynamics 3 |
Other Description | TCPTP-interacting protein 51|cerebral protein 10|family with sequence similarity 82, member A2|family with sequence similarity 82, member C|microtubule-associated protein|protein tyrosine phosphatase-interacting protein 51|regulator of microtubule dynamics protein 3 |
Swissprots | Q96SD6 Q96H23 A9UMZ9 Q96TC7 Q9H6G1 Q6ZWE9 B3KRR3 Q9NVQ6 |
Accessions | CAC33289 CAC38596 CAC39480 CAE89415 EAW92436 EAW92437 EAW92438 EAW92439 EAW92440 EAW92441 Q96TC7 AA772280 AB000782 BAB46923 AK001441 BAA91693 AK025963 BAB15298 AK090731 AK092058 BAG52475 AK097286 BAG53446 AK123192 BAC85554 AK123282 BAG53885 AY358793 AAQ89153 BC008970 AAH08970 BC063844 AAH63844 BR000691 FAA00416 DA280017 DA592879 HQ447480 ADQ31966 XM_005254531 XP_005254588 XM_011521755 XP_011520057 NM_001304802 NP_001291731 NM_018145 NP_060615 |
Function | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}. |
Subcellular Location | Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. |
Tissue Specificity | Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed. {ECO:0000269|PubMed:15609043, ECO:0000269|PubMed:16820967}. |
Human FAM82A2 full length protein - ab163000 from Abcam
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RMDN3 Antibody Blocking Peptide - LS-E17180 from LifeSpan Bioscience
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Recombinant Human PTPIP51 Protein - H00055177-P01 from Novus Biologicals
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FAM82A2-Antibody-Center-Blocking-Peptide - BP17075c from Abgent, a WuXi AppTec company
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FAM82C Blocking Peptide - 33R-5411 from Fitzgerald
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FAM82A2 - H00055177-P01-10 from Acris Antibodies
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FAM82A2 - H00055177-P01-25 from Acris Antibodies
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PTPIP51 fusion protein - Ag15135 from Proteintech Group
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PTPIP51 fusion protein - Ag14708 from Proteintech Group
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Recombinant Human RMDN3, His-tagged - RMDN3-2054H from Creative Biomart
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Recombinant Human Regulator of microtubule dynamics protein 3(FAM82A2) ,partial - CSB-YP836307HU CSB-BP836307HU CSB-MP836307HU from Cusabio
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Recombinant human Regulator of microtubule dynamics protein 3 - CSB-EP836307HU from Cusabio
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PTPIP51 Protein - NBP1-84738PEP from Novus Biologicals
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FAM82A2 Peptide, Human - M34GP05490H from Creative Peptides
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RMDN3 Recombinant Protein (OPCA02375) - OPCA02375 from Aviva Systems Biology
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FAM82A2 Antibody - SH-A12037 from Novatein Biosciences
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Recombinant human Regulator of microtubule dynamics protein 3 - AP71420 from Signalway Antibody
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Regulator of microtubule dynamics protein 3, Recombinant Protein - MBS969737 from MyBioSource
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Regulator of microtubule dynamics protein 3, Recombinant Protein - MBS9421284 from MyBioSource
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Human RMDN3 protein - orb244891 from Biorbyt
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