| Gene Symbol |
OAZ1
|
| Entrez Gene |
4946
|
| Alt Symbol |
AZI, OAZ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ornithine decarboxylase antizyme 1
|
| Other Description |
ODC-Az|antizyme 1
|
| Swissprots |
Q9UPL9 Q92595 Q14989 O43382 P54368
|
| Accessions |
AAC02802 AAC02803 AAW56074 BAA23101 EAW69393 EAW69394 EAW69395 P54368 AF090094 AK307221 AL542477 BC007247 BC010063 BC013037 BC035151 BC042364 BC053360 BC055397 BC081537 BC093652 AAH93652 BC100291 BC112133 AAI12134 BI667301 BM423450 D78361 BAA11373 D87914 BAA13497 HY050868 U09202 AAA82154 NM_001301020 NP_001287949 NM_004152 NP_004143
|
| Function |
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:17900240}.
|
