Gene Symbol | TPSAB1 |
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Entrez Gene | 7177 |
Alt Symbol | TPS1, TPS2, TPSB1 |
Species | Human |
Gene Type | protein-coding |
Description | tryptase alpha/beta 1 |
Other Description | mast cell alpha II tryptase|mast cell beta I tryptase|tryptase I|tryptase alpha II|tryptase alpha-1|tryptase alpha/beta-1|tryptase beta 1|tryptase beta I|tryptase beta-1|tryptase-1|tryptase-I|tryptase-III |
Swissprots | Q15664 D2E6S0 Q9UQI1 Q9H2Y4 Q6B052 Q15661 Q9UQI7 P20231 O95827 Q9UQI6 D2E6S1 Q15663 P15157 D2E6S2 D2E6R9 Q9H2Y5 |
Accessions | AAC83172 AAD17846 AAD17860 AAK61271 ACZ98911 Q15661 AF206665 AAG35695 AF206666 AAG35696 AF206667 AAG35697 BC028059 AAH28059 BC038416 BC051852 AAH51852 BC074974 AAH74974 BC074975 AAH74975 CR541836 CAG46635 FJ931118 ACZ98912 M30038 AAA86934 M33491 AAA36778 NM_003294 NP_003285 |
Function | Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted. Note=Released from the secretory granules upon mast cell activation. |
Mast Cell Tryptase CRISPR/Cas9 KO Plasmid (h) - sc-400887 from Santa Cruz Biotechnology
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Mast Cell Tryptase HDR Plasmid (h) - sc-400887-HDR from Santa Cruz Biotechnology
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Mast Cell Tryptase Double Nickase Plasmid (h) - sc-400887-NIC from Santa Cruz Biotechnology
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Mast Cell Tryptase Double Nickase Plasmid (h2) - sc-400887-NIC-2 from Santa Cruz Biotechnology
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Mast Cell Tryptase CRISPR Activation Plasmid (h) - sc-400887-ACT from Santa Cruz Biotechnology
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Mast Cell Tryptase CRISPR Activation Plasmid (h2) - sc-400887-ACT-2 from Santa Cruz Biotechnology
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Mast Cell Tryptase Lentiviral Activation Particles (h) - sc-400887-LAC from Santa Cruz Biotechnology
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Mast Cell Tryptase Lentiviral Activation Particles (h2) - sc-400887-LAC-2 from Santa Cruz Biotechnology
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Mast Cell Tryptase siRNA (h) - sc-43910 from Santa Cruz Biotechnology
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Mast Cell Tryptase shRNA Plasmid (h) - sc-43910-SH from Santa Cruz Biotechnology
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Mast Cell Tryptase shRNA (h) Lentiviral Particles - sc-43910-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN21886 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21886 from Sigma-Aldrich
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TPSAB1 siRNA (Human) - CRH4927 from Cohesion Biosciences
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Tryptase alpha/TPS1 RNAi - H00007177-R01 from Novus Biologicals
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TPSAB1 - MBS8232613 from MyBioSource
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TPSB2 - MBS8217742 from MyBioSource
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Mast Cell Tryptase CRISPR/Cas9 KO Plasmid (h2) - sc-400887-KO-2 from Santa Cruz Biotechnology
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Mast Cell Tryptase HDR Plasmid (h2) - sc-400887-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TPSAB1 (NM_003294.3) - SHH433520 from Creative biogene
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Human TPSAB1 siRNA - orb265429 from Biorbyt
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TPSAB1 shRNA Plasmid (Human) - CHH4927 from Cohesion Biosciences
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TPSAB1 miRNA 3'UTR clone - MiUTR1H-10681 from Creative biogene
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