| Gene Symbol |
ADIPOR1
|
| Entrez Gene |
51094
|
| Alt Symbol |
ACDCR1, CGI-45, CGI45, PAQR1, TESBP1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adiponectin receptor 1
|
| Other Description |
adiponectin receptor protein 1|progestin and adipoQ receptor family member I
|
| Swissprots |
Q96A54 Q9Y360 Q53YY6 B3KMB0 Q53HS7
|
| Accessions |
CBJ06650 CBS99526 EAW91449 EAW91450 Q96A54 AF125179 AAQ13552 AF125180 AAQ13553 AF151803 AAD34040 AI251444 AK001484 BAG50922 AK058114 AK124455 AK222503 BAD96223 AY424279 AAR08367 BC001594 AAH01594 BC010743 AAH10743 BI597715 BX461217 DA523648 HQ448254 ADQ32734 NM_001290553 NP_001277482 NM_001290557 NP_001277486 NM_001290629 NP_001277558 NM_015999 NP_057083 NR_046083
|
| Function |
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. {ECO:0000269|PubMed:12802337}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:12802337}; Multi-pass membrane protein {ECO:0000269|PubMed:12802337}. Note=Localized to the cell membrane and intracellular organelles.
|
| Tissue Specificity |
Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:16044242}.
|
| Top Pathways |
Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway
|