Gene Symbol | ADIPOR1 |
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Entrez Gene | 51094 |
Alt Symbol | ACDCR1, CGI-45, CGI45, PAQR1, TESBP1A |
Species | Human |
Gene Type | protein-coding |
Description | adiponectin receptor 1 |
Other Description | adiponectin receptor protein 1|progestin and adipoQ receptor family member I |
Swissprots | Q96A54 Q9Y360 Q53YY6 B3KMB0 Q53HS7 |
Accessions | CBJ06650 CBS99526 EAW91449 EAW91450 Q96A54 AF125179 AAQ13552 AF125180 AAQ13553 AF151803 AAD34040 AI251444 AK001484 BAG50922 AK058114 AK124455 AK222503 BAD96223 AY424279 AAR08367 BC001594 AAH01594 BC010743 AAH10743 BI597715 BX461217 DA523648 HQ448254 ADQ32734 NM_001290553 NP_001277482 NM_001290557 NP_001277486 NM_001290629 NP_001277558 NM_015999 NP_057083 NR_046083 |
Function | Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. {ECO:0000269|PubMed:12802337}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:12802337}; Multi-pass membrane protein {ECO:0000269|PubMed:12802337}. Note=Localized to the cell membrane and intracellular organelles. |
Tissue Specificity | Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. {ECO:0000269|PubMed:12802337, ECO:0000269|PubMed:16044242}. |
Top Pathways | Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
Adiponectin Receptor 1 peptide (361-375) - ab45719 from Abcam
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Human Adiponectin Receptor 1 full length protein - ab153327 from Abcam
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Human Adiponectin Receptor 1 peptide - ab59184 from Abcam
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Human Adiponectin Receptor 1 protein fragment - ab153328 from Abcam
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ADIPOR1/Adiponectin Receptor 1 Antibody Blocking Peptide - LS-E23102 from LifeSpan Bioscience
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ADIPOR1/Adiponectin Receptor 1 Antibody Blocking Peptide - LS-E23103 from LifeSpan Bioscience
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ADIPOR1/Adiponectin Receptor 1 Antibody Blocking Peptide - LS-E9689 from LifeSpan Bioscience
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Recombinant Human AdipoR1 Protein - H00051094-Q01 from Novus Biologicals
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Recombinant Human AdipoR1 Protein - H00051094-P01 from Novus Biologicals
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ADIPOR1-Antibody-C-term-Blocking-Peptide - BP8634b from Abgent, a WuXi AppTec company
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Adiponectin Receptor 1 blocking peptide - GTX89569-PEP from GeneTex
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AdipoR1 Blocking Peptide - 33R-11012 from Fitzgerald
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Human Adiponectin Receptor 1 Protein - abx065171 from Abbexa
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Human Adiponectin Receptor 1 Protein - abx065172 from Abbexa
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Adiponectin Receptor 1 - H00051094-P01 from Acris Antibodies
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Adiponectin Receptor 1 - H00051094-Q01-10 from Acris Antibodies
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Adiponectin Receptor 1 - H00051094-Q01-25 from Acris Antibodies
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Adiponectin Receptor 1 Control Peptide - AP05202CP-N from Acris Antibodies
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Adiponectin Receptor 1 (ADIPOR1), Human - 20-6353 from ARP American Research Products
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Adiponectin Receptor 1 (ADIPOR1), Human - 20-6354 from ARP American Research Products
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ADIPOR1 fusion protein - Ag18187 from Proteintech Group
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Recombinant Human ADIPOR1, GST-tagged - ADIPOR1-9426H from Creative Biomart
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Recombinant Human ADIPOR1, GST-tagged - ADIPOR1-625H from Creative Biomart
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Recombinant Human ADIPOR1, His-tagged, MBP tagged - ADIPOR1-3199H from Creative Biomart
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Recombinant Adiponectin Receptor 1 (ADIPOR1) - RPA147Hu01 from Uscn Life Science Inc.
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