Gene Symbol | Pou3f3 |
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Entrez Gene | 18993 |
Alt Symbol | Brn-1, Brn1, Otf8, Skin1 |
Species | Mouse |
Gene Type | protein-coding |
Description | POU domain, class 3, transcription factor 3 |
Other Description | OTF-8|brain-1|brain-specific homeobox/POU domain protein 1|oct-8|octamer-binding protein 8|octamer-binding transcription factor 8 |
Swissprots | P31361 |
Accessions | AAA39960 P31361 BC079869 BC156037 AAI56038 CA315285 CD774392 CJ064353 NM_008900 NP_032926 |
Function | Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3'). {ECO:0000250, ECO:0000269|PubMed:10473120, ECO:0000269|PubMed:12130536, ECO:0000269|PubMed:19527706}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00530, ECO:0000269|PubMed:10473120}. |
Tissue Specificity | Brain. |
Brn-1 CRISPR/Cas9 KO Plasmid (m) - sc-422352 from Santa Cruz Biotechnology
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Brn-1 HDR Plasmid (m) - sc-422352-HDR from Santa Cruz Biotechnology
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Brn-1 Double Nickase Plasmid (m) - sc-422352-NIC from Santa Cruz Biotechnology
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Brn-1 Double Nickase Plasmid (m2) - sc-422352-NIC-2 from Santa Cruz Biotechnology
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Brn-1 CRISPR Activation Plasmid (m) - sc-422352-ACT from Santa Cruz Biotechnology
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Brn-1 CRISPR Activation Plasmid (m2) - sc-422352-ACT-2 from Santa Cruz Biotechnology
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Brn-1 Lentiviral Activation Particles (m) - sc-422352-LAC from Santa Cruz Biotechnology
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Brn-1 Lentiviral Activation Particles (m2) - sc-422352-LAC-2 from Santa Cruz Biotechnology
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Brn-1 siRNA (m) - sc-29836 from Santa Cruz Biotechnology
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Brn-1 shRNA Plasmid (m) - sc-29836-SH from Santa Cruz Biotechnology
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Brn-1 shRNA (m) Lentiviral Particles - sc-29836-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN39087 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39087 from Sigma-Aldrich
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POU3F3 siRNA (Mouse) - CRM3169 from Cohesion Biosciences
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shRNA set against Mouse POU3F3 (NM_008900.2) - SHH380092 from Creative biogene
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shRNA set against Mouse Pou3f3(NM_008900.2) - SHR129910 from Creative biogene
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Mouse POU3F3 siRNA - orb282645 from Biorbyt
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POU3F3 shRNA Plasmid (Mouse) - CHM3169 from Cohesion Biosciences
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POU3F3 miRNA 3'UTR clone - MiUTR1M-09433 from Creative biogene
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