Gene Symbol | ATAD3A |
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Entrez Gene | 55210 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | ATPase family, AAA domain containing 3A |
Other Description | ATPase family AAA domain-containing protein 3A |
Swissprots | Q8N275 Q9NVI7 D2K8Q1 G3V1I6 Q96A50 Q5SV23 B3KPB3 |
Accessions | EAW56186 EAW56187 EAW56188 EAW56189 EAW56190 EAW56191 Q9NVI7 AK001571 BAA91764 AK025865 AK056099 BAG51625 AK091144 BAC03595 AK092833 AK310572 BC007803 AAH07803 BC011814 AAH11814 BC014101 AAH14101 BC033109 AAH33109 BC063607 AAH63607 DA206969 GU189416 ACZ80514 NM_001170535 NP_001164006 NM_001170536 NP_001164007 NM_018188 NP_060658 |
Function | Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis. {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275}. |
Subcellular Location | Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N- terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids. |
Tissue Specificity | Overexpressed in lung adenocarcinomas (at protein level). {ECO:0000269|PubMed:20332122}. |
ATAD3A CRISPR/Cas9 KO Plasmid (h) - sc-405546 from Santa Cruz Biotechnology
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ATAD3A HDR Plasmid (h) - sc-405546-HDR from Santa Cruz Biotechnology
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ATAD3A Double Nickase Plasmid (h) - sc-405546-NIC from Santa Cruz Biotechnology
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ATAD3A Double Nickase Plasmid (h2) - sc-405546-NIC-2 from Santa Cruz Biotechnology
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ATAD3A CRISPR Activation Plasmid (h) - sc-405546-ACT from Santa Cruz Biotechnology
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ATAD3A CRISPR Activation Plasmid (h2) - sc-405546-ACT-2 from Santa Cruz Biotechnology
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ATAD3A Lentiviral Activation Particles (h) - sc-405546-LAC from Santa Cruz Biotechnology
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ATAD3A Lentiviral Activation Particles (h2) - sc-405546-LAC-2 from Santa Cruz Biotechnology
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ATAD3A siRNA (h) - sc-88047 from Santa Cruz Biotechnology
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ATAD3A shRNA Plasmid (h) - sc-88047-SH from Santa Cruz Biotechnology
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ATAD3A shRNA (h) Lentiviral Particles - sc-88047-V from Santa Cruz Biotechnology
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ATAD3A RNAi - H00055210-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN3626 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3626 from Sigma-Aldrich
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ATAD3A siRNA (Human) - CRJ0560 from Cohesion Biosciences
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ATAD3A - MBS8222816 from MyBioSource
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ATAD3A shRNA Plasmid (Human) - CHJ0560 from Cohesion Biosciences
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ATAD3A miRNA 3'UTR clone - MiUTR3H-12379 from Creative biogene
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