| Gene Symbol |
BEX1
|
| Entrez Gene |
55859
|
| Alt Symbol |
BEX2, HBEX2, HGR74-h
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
brain expressed, X-linked 1
|
| Other Description |
brain-expressed X-linked protein 1|ovarian granulosa cell 13.0 kDa protein hGR74|protein BEX1
|
| Swissprots |
A8K4J3 A0AVN1 Q9HBH7 Q9NZ33
|
| Accessions |
EAW54723 Q9HBH7 AF183416 AAG09685 AF220189 AAF67654 AF237783 AAG09752 AK290958 BAF83647 AY833561 AAX40679 BC018615 BC105298 BC126427 AAI26428 BC126429 AAI26430 BM465948 BX098763 HQ258716 ADR83467 NM_018476 NP_060946
|
| Function |
Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Expressed in lung, skeletal muscle, peripheral blood leukocyte, stomach, lymph node, trachea and bone marrow. Highly expressed in acute myeloid leukemia. {ECO:0000269|PubMed:11989783, ECO:0000269|PubMed:15920485, ECO:0000269|PubMed:15958283}.
|
![Western Blot: Bex1 Overexpression Lysate (Adult Normal) [NBP2-06797] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Bex1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1680_Bex1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06797-img0001.jpg)