| Gene Symbol |
RLBP1
|
| Entrez Gene |
6017
|
| Alt Symbol |
CRALBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinaldehyde binding protein 1
|
| Other Description |
cellular retinaldehyde-binding protein|cellular retinaldehyde-binding protein-1|retinaldehyde-binding protein 1
|
| Swissprots |
P12271 B2R667
|
| Accessions |
AAA65123 EAX02038 P12271 AK312457 BAG35364 BC004199 AAH04199 BF940774 BG205561 BM704704 BM921294 BX490622 DQ980611 J04213 AAA60251 XM_011521870 XP_011520172 XM_011521871 XP_011520173 XM_011521872 XP_011520174 NM_000326 NP_000317
|
| Function |
Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. {ECO:0000269|PubMed:19846785}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Retina and pineal gland. Not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina. {ECO:0000269|PubMed:19846785}.
|
![Western Blot: CRALBP Overexpression Lysate (Adult Normal) [NBL1-15383] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CRALBP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2606_CRALBP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15383-img0002.jpg)