Gene Symbol | RLBP1 |
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Entrez Gene | 6017 |
Alt Symbol | CRALBP |
Species | Human |
Gene Type | protein-coding |
Description | retinaldehyde binding protein 1 |
Other Description | cellular retinaldehyde-binding protein|cellular retinaldehyde-binding protein-1|retinaldehyde-binding protein 1 |
Swissprots | P12271 B2R667 |
Accessions | AAA65123 EAX02038 P12271 AK312457 BAG35364 BC004199 AAH04199 BF940774 BG205561 BM704704 BM921294 BX490622 DQ980611 J04213 AAA60251 XM_011521870 XP_011520172 XM_011521871 XP_011520173 XM_011521872 XP_011520174 NM_000326 NP_000317 |
Function | Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. {ECO:0000269|PubMed:19846785}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Retina and pineal gland. Not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina. {ECO:0000269|PubMed:19846785}. |
CRALBP CRISPR/Cas9 KO Plasmid (h) - sc-402092 from Santa Cruz Biotechnology
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CRALBP HDR Plasmid (h) - sc-402092-HDR from Santa Cruz Biotechnology
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CRALBP Double Nickase Plasmid (h) - sc-402092-NIC from Santa Cruz Biotechnology
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CRALBP Double Nickase Plasmid (h2) - sc-402092-NIC-2 from Santa Cruz Biotechnology
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CRALBP CRISPR Activation Plasmid (h) - sc-402092-ACT from Santa Cruz Biotechnology
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CRALBP CRISPR Activation Plasmid (h2) - sc-402092-ACT-2 from Santa Cruz Biotechnology
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CRALBP Lentiviral Activation Particles (h) - sc-402092-LAC from Santa Cruz Biotechnology
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CRALBP Lentiviral Activation Particles (h2) - sc-402092-LAC-2 from Santa Cruz Biotechnology
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CRALBP siRNA (h) - sc-40428 from Santa Cruz Biotechnology
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CRALBP shRNA Plasmid (h) - sc-40428-SH from Santa Cruz Biotechnology
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CRALBP shRNA (h) Lentiviral Particles - sc-40428-V from Santa Cruz Biotechnology
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CRALBP RNAi - H00006017-R01 from Novus Biologicals
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MISSION® esiRNA - EHU155411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18304 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18304 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03344 from Sigma-Aldrich
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RLBP1 siRNA (Human) - CRH4083 from Cohesion Biosciences
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RLBP1 - MBS8204537 from MyBioSource
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shRNA set against Human RLBP1 (NM_000326.4) - SHH396097 from Creative biogene
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RLBP1 shRNA Plasmid (Human) - CHH4083 from Cohesion Biosciences
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RLBP1 miRNA 3'UTR clone - MiUTR1H-08839 from Creative biogene
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