| Gene Symbol | AGTPBP1 |
|---|---|
| Entrez Gene | 23287 |
| Alt Symbol | CCP1, NNA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP/GTP binding protein 1 |
| Other Description | ATP/GTP-binding protein 1|carboxypeptidase-tubulin|cytosolic carboxypeptidase 1|nervous system nuclear protein induced by axotomy protein 1 homolog|soluble carboxypeptidase|tubulinyl-Tyr carboxypeptidase|tyrosine carboxypeptidase |
| Swissprots | Q5VV80 Q9H8U6 Q658P5 Q9NVK1 B4DRZ8 Q63HM7 Q6P9D6 Q9H9W8 Q9UPW5 B4DIT6 |
| Accessions | EAW62694 EAW62695 EAW62696 EAW62697 EAW62698 EAW62699 Q9UPW5 AB028958 BAA82987 AJ420433 AJ437018 CAD24587 AK001544 BAA91749 AK022562 BAB14100 AK023280 BAB14505 AK024698 AK295304 BAG58284 AK295774 BAG58598 AK299506 BAG61460 AL833359 CAH56222 BC060815 AAH60815 BX648366 CAH56158 CA449535 DC334722 XM_005251847 XP_005251904 XM_005251848 XP_005251905 XM_005251849 XP_005251906 XM_011518418 XP_011516720 XM_011518419 XP_011516721 XM_011518420 XP_011516722 XM_011518421 XP_011516723 NM_001286715 NP_001273644 NM_001286717 NP_001273646 NM_015239 NP_056054 |
| Function | Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250|UniProtKB:Q641K1}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:23085998}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q641K1}. Nucleus {ECO:0000269|PubMed:23085998}. Mitochondrion {ECO:0000250|UniProtKB:Q641K1}. Note=Localizes in both the cytoplasm and nuclei of interphase and dividing cells. {ECO:0000269|PubMed:23085998}. |