| Gene Symbol |
SLC5A1
|
| Entrez Gene |
6523
|
| Alt Symbol |
D22S675, NAGT, SGLT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 5 (sodium/glucose cotransporter), member 1
|
| Other Description |
Na+/glucose cotransporter 1|high affinity sodium-glucose cotransporter|sodium/glucose cotransporter 1
|
| Swissprots |
B7Z4Q9 B2R7E2 B7ZA69 P13866
|
| Accessions |
AAB59448 EAW60006 P13866 AI078794 AK297665 BAH12645 AK312948 BAG35789 AK316184 BAH14555 BC139838 AAI39839 BC139839 AAI39840 BC141435 AAI41436 BC146580 AAI46581 BM980416 CR456579 CAG30465 CU013176 CAK54607 CU013464 CAK54906 DA429018 DA562836 DQ656053 M24847 AAA60320 XM_011530331 XP_011528633 NM_000343 NP_000334 NM_001256314 NP_001243243
|
| Function |
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed mainly in intestine and kidney.
|
| Top Pathways |
Bile secretion, Carbohydrate digestion and absorption, Mineral absorption
|
![Western Blot: SGLT1 Overexpression Lysate (Adult Normal) [NBL1-16171] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SGLT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2595_SGLT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16171-img0001.jpg)