Gene Symbol | SLC5A1 |
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Entrez Gene | 6523 |
Alt Symbol | D22S675, NAGT, SGLT1 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
Other Description | Na+/glucose cotransporter 1|high affinity sodium-glucose cotransporter|sodium/glucose cotransporter 1 |
Swissprots | B7Z4Q9 B2R7E2 B7ZA69 P13866 |
Accessions | AAB59448 EAW60006 P13866 AI078794 AK297665 BAH12645 AK312948 BAG35789 AK316184 BAH14555 BC139838 AAI39839 BC139839 AAI39840 BC141435 AAI41436 BC146580 AAI46581 BM980416 CR456579 CAG30465 CU013176 CAK54607 CU013464 CAK54906 DA429018 DA562836 DQ656053 M24847 AAA60320 XM_011530331 XP_011528633 NM_000343 NP_000334 NM_001256314 NP_001243243 |
Function | Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed mainly in intestine and kidney. |
Top Pathways | Bile secretion, Carbohydrate digestion and absorption, Mineral absorption |
SGLT-1 CRISPR/Cas9 KO Plasmid (h) - sc-401588 from Santa Cruz Biotechnology
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SGLT-1 HDR Plasmid (h) - sc-401588-HDR from Santa Cruz Biotechnology
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SGLT-1 Double Nickase Plasmid (h) - sc-401588-NIC from Santa Cruz Biotechnology
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SGLT-1 Double Nickase Plasmid (h2) - sc-401588-NIC-2 from Santa Cruz Biotechnology
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SGLT-1 CRISPR Activation Plasmid (h) - sc-401588-ACT from Santa Cruz Biotechnology
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SGLT-1 CRISPR Activation Plasmid (h2) - sc-401588-ACT-2 from Santa Cruz Biotechnology
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SGLT-1 Lentiviral Activation Particles (h) - sc-401588-LAC from Santa Cruz Biotechnology
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SGLT-1 Lentiviral Activation Particles (h2) - sc-401588-LAC-2 from Santa Cruz Biotechnology
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SGLT-1 siRNA (h) - sc-61538 from Santa Cruz Biotechnology
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SGLT-1 shRNA Plasmid (h) - sc-61538-SH from Santa Cruz Biotechnology
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SGLT-1 shRNA (h) Lentiviral Particles - sc-61538-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU020551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1685 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1685 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12103 from Sigma-Aldrich
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SLC5A1 siRNA (Human) - CRH4417 from Cohesion Biosciences
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SGLT1/SLC5A1 RNAi - H00006523-R01 from Novus Biologicals
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SLC5A1 - MBS827189 from MyBioSource
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shRNA set against Human SLC5A1 (NM_000343.3) - SHH411640 from Creative biogene
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SLC5A1 shRNA Plasmid (Human) - CHH4417 from Cohesion Biosciences
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SLC5A1 miRNA 3'UTR clone - MiUTR4H-TG08118 from Creative biogene
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