| Gene Symbol |
PTK2
|
| Entrez Gene |
5747
|
| Alt Symbol |
FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine kinase 2
|
| Other Description |
FADK 1|FAK-related non-kinase polypeptide|PTK2 protein tyrosine kinase 2|focal adhesion kinase 1|focal adhesion kinase isoform FAK-Del33|focal adhesion kinase-related nonkinase|protein phosphatase 1 regulatory subunit 71|protein phosphatase 1, regulatory subunit 71
|
| Swissprots |
Q14291 Q8IYN9 Q9UD85 Q05397 F5H4S4 J3QT16 B4E2N6
|
| Accessions |
EAW92210 EAW92211 EAW92212 EAW92213 EAW92214 Q05397 AB209071 BAD92308 AB209083 BAD92320 AK055139 AK094999 BAC04470 AK124810 AK294873 BAG57974 AK301557 BAG63053 AK304356 BAG65198 AL832961 CAH56296 BC015361 BC028733 AAH28733 BC035404 AAH35404 BC043202 BF434494 DA236314 DA994616 DB478006 EU176794 ABW03595 KF437463 AHZ89389 L13616 AAA58469 XM_005251003 XP_005251060 XM_005251012 XP_005251069 XM_005251013 XP_005251070 XM_005251014 XP_005251071 XM_006716606 XP_006716669 XM_006716608 XP_006716671 XM_006716609 XP_006716672 XM_006716610 XP_006716673 XM_011517180 XP_011515482 XM_011517181 XP_011515483 XM_011517182 XP_011515484 XM_011517183 XP_011515485 XM_011517184 XP_011515486 XM_011517185 XP_011515487 XM_011517186 XP_011515488 XM_011517187 XP_011515489 XM_011517188 XP_011515490 XM_011517189 XP_011515491 XM_011517190 XP_011515492 XM_011517191 XP_011515493 XM_011517192 XP_011515494 XM_011517193 XP_011515495 XM_011517194 XP_011515496 XM_011517195 XP_011515497 XM_011517196 XP_011515498 XM_011517197 XP_011515499 XM_011517198 XP_011515500 NM_001199649 NP_001186578 NM_005607 NP_005598 NM_153831 NP_722560
|
| Function |
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additi
|
| Subcellular Location |
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus. Note=Constituent of focal adhesions. Detected at microtubules.
|
| Tissue Specificity |
Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous. {ECO:0000269|PubMed:20109444, ECO:0000269|PubMed:7692878, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:8422239}.
|
| Top Pathways |
Proteoglycans in cancer, PI3K-Akt signaling pathway, Amoebiasis, Axon guidance, Bacterial invasion of epithelial cells
|
