PTK2

Gene Symbol PTK2
Entrez Gene 5747
Alt Symbol FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK
Species Human
Gene Type protein-coding
Description protein tyrosine kinase 2
Other Description FADK 1|FAK-related non-kinase polypeptide|PTK2 protein tyrosine kinase 2|focal adhesion kinase 1|focal adhesion kinase isoform FAK-Del33|focal adhesion kinase-related nonkinase|protein phosphatase 1 regulatory subunit 71|protein phosphatase 1, regulatory subunit 71
Swissprots Q14291 Q8IYN9 Q9UD85 Q05397 F5H4S4 J3QT16 B4E2N6
Accessions EAW92210 EAW92211 EAW92212 EAW92213 EAW92214 Q05397 AB209071 BAD92308 AB209083 BAD92320 AK055139 AK094999 BAC04470 AK124810 AK294873 BAG57974 AK301557 BAG63053 AK304356 BAG65198 AL832961 CAH56296 BC015361 BC028733 AAH28733 BC035404 AAH35404 BC043202 BF434494 DA236314 DA994616 DB478006 EU176794 ABW03595 KF437463 AHZ89389 L13616 AAA58469 XM_005251003 XP_005251060 XM_005251012 XP_005251069 XM_005251013 XP_005251070 XM_005251014 XP_005251071 XM_006716606 XP_006716669 XM_006716608 XP_006716671 XM_006716609 XP_006716672 XM_006716610 XP_006716673 XM_011517180 XP_011515482 XM_011517181 XP_011515483 XM_011517182 XP_011515484 XM_011517183 XP_011515485 XM_011517184 XP_011515486 XM_011517185 XP_011515487 XM_011517186 XP_011515488 XM_011517187 XP_011515489 XM_011517188 XP_011515490 XM_011517189 XP_011515491 XM_011517190 XP_011515492 XM_011517191 XP_011515493 XM_011517192 XP_011515494 XM_011517193 XP_011515495 XM_011517194 XP_011515496 XM_011517195 XP_011515497 XM_011517196 XP_011515498 XM_011517197 XP_011515499 XM_011517198 XP_011515500 NM_001199649 NP_001186578 NM_005607 NP_005598 NM_153831 NP_722560
Function Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additi
Subcellular Location Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus. Note=Constituent of focal adhesions. Detected at microtubules.
Tissue Specificity Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous. {ECO:0000269|PubMed:20109444, ECO:0000269|PubMed:7692878, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:8422239}.
Top Pathways Proteoglycans in cancer, PI3K-Akt signaling pathway, Amoebiasis, Axon guidance, Bacterial invasion of epithelial cells

Phospho-FAK (Tyr576/577) Antibody - 3281 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells, untreated or treated with anti-CD3 antibody (1 µg/ml for 10 minutes), using Phospho-FAK (Tyr576/577) Antibody (upper) or FAK antibody (lower).

Phospho-FAK (Tyr397) (D20B1) Rabbit mAb - 8556 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D20B1
Western blot analysis of extracts from A549 cells, untreated or treated with calf intestinal phosphatase (CIP), using Phospho-FAK (Tyr397) (D20B1) Rabbit mAb (upper) and FAK Antibody #3285 (lower).

Phospho-FAK (Tyr397) Antibody - 3283 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3 cells, untransfected or transfected with activated Src, using Phospho-FAK (Tyr397) Antibody (upper) or FAK Antibody #3285 (lower).

Phospho-FAK (Tyr925) Antibody - 3284 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells, untreated or anti-CD3 antibody-treated (1 µg/ml for 10 minutes), using Phospho-FAK (Tyr925) Antibody (upper) or FAK antibody (lower).

FAK (D2R2E) Rabbit mAb - 13009 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2R2E
Western blot analysis of extracts from various cell lines using FAK (D2R2E) Rabbit mAb.

FAK Antibody - 3285 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using FAK Antibody.

FAK (B-8) - sc-271195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAK (B-8): sc-271195. Western blot analysis of FAK expression in HeLa whole cell lysate.

FAK (C-20) - sc-558 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of FAK expression in HeLa whole cell lysate (A). Western blot analysis of 20 ng of mouse recombinat FAK fusion protein (B) and an equal amount of an unrelated fusion protein (C). Antibodies tested include FAK (C-20)-G: sc-558-G (A) and FAK (C-20): sc-558 (B,C).

FAK (D-1) - sc-271126 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAK (D-1): sc-271126. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic and nuclear staining of urothelial cells.

FAK (C-903) - sc-932 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of FAK expression in U-937 (A,B) whole cell lysates. Antibodies tested include FAK (C-20): sc-558 (A) and FAK (C-903): sc-932 (B).

FAK (H-1) - sc-1688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FAK (H-1): sc-1688. Western blot analysis of FAK expression in HeLa whole cell lysate.

FAK (A-17) - sc-557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FAK (A-17): sc-557. Western blot analysis of FAK expression in Jurkat (A), Ramos (B), HeLa (C), SK-BR-3 (D), MCF7 (E) and U-937 (F) whole cell lysates.

p-FAK (A-12) - sc-374668 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of FAK phosphorylation in non-transfected: sc-117752 (A,D), untreated human FAK transfected: sc-114600 (B,E) and lambda protein phosphatase (sc-200312A) treated human FAK transfected: sc-114600 (C,F) 293T whole cell lysates. Antibodies tested include p-FAK (A-12): sc-374668 (A,B,C) and FAK (C-903): sc-932 (D,E,F).

p-FAK (Ser 722) - sc-16662 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of FAK phosphorylation in NIH/3T3 cells treated with anisomycin. Blots were probed with FAK (C-20): sc-558 (A), p-FAK (Ser 722)-R: sc-16662-R preincubated with its cognate phosphorylated peptide (B) and p-FAK (Ser 722)-R: sc-16662-R preincubated with its cognate non-phosphorylated peptide (C).

p-FAK (Ser 910) - sc-16666 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-FAK (Tyr 407) - sc-16664 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-FAK (Tyr 407): sc-16664. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic and nuclear staining of urothelial cells.

p-FAK (Tyr 576/577) - sc-21831 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-FAK (Tyr 576/577): sc-21831. Western blot analysis of FAK phosphorylation in non-transfected: sc-117752 (A), untreated human FAK transfected: sc-114600 (B) and lambda protein phosphatase (sc-200312A) treated human FAK transfected: sc-114600 (C) 293T whole cell lysates.

p-FAK (Tyr 577) - sc-16665 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-FAK (Tyr 577): sc-16665. Western blot analysis of FAK phosphorylation in non-transfected: sc-117752 (A) and human FAK transfected: sc-114600 (B) 293T whole cell lysates.

p-FAK (Tyr 861) - sc-16663 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-FAK (Tyr 861)-R: sc-16663-R. Western blot analysis of FAK phosphorylation in non-transfected: sc-117752 (A), untreated human FAK transfected: sc-114600 (B) and lambda protein phosphatase treated human FAK transfected: sc-114600 (C) 293T whole cell lysates.

p-FAK (Tyr 925) - sc-11766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-FAK (Tyr 925): sc-11766. Western blot analysis of FAK phosphorylation in non-transfected: sc-117752 (A) and human FAK transfected: sc-114600 (B) 293T whole cell lysates.

p-FAK (2D11) - sc-81493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
p-FAK (2D11): sc-81493. Western blot analysis of FAK phosphorylation in non-transfected: sc-117752 (A) and human FAK transfected: sc-114600 (B) 293T whole cell lysates.

p-FAK (Tyr 925) - sc-101680 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of phosphorylated FAK expression in Hep G2 (A,B) and serum-treated 293 (C) whole cell lysates. Blots were probed with p-FAK (Tyr 925): sc-101680 preincubated with cognate phosphorylated peptide (A) and p-FAK (Tyr 925): sc-101680 (B,C,D).

Anti-FAK (phospho S843) antibody - ab195954 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FAK (phospho S843) antibody (ab195954) at 1/500 dilutionLane 1 : PMA-treated HepG2 whole cell lysate with antigen-specific peptideLane 2 : PMA-treated HepG2 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-FAK (phospho S910) antibody - ab61051 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab61051 at 1/100 dilution staining FAK in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-FAK (phospho Y397) antibody - ab194935 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FAK (phospho Y397) antibody (ab194935) at 1/500 dilutionLane 1 : Untreated 293 cell extractsLane 2 : EGF-treated 293 cell extracts
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