TRPM4

Gene Symbol TRPM4
Entrez Gene 54795
Alt Symbol PFHB1B, TRPM4B
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily M, member 4
Other Description LTrpC4|calcium-activated non-selective cation channel 1|hTRPM4|long transient receptor potential channel 4|melastatin-4|transient receptor potential cation channel subfamily M member 4
Swissprots Q7Z5D9 A2RU25 Q96L84 Q8TD43 Q9NXV1
Accessions CAC69808 EAW52460 EAW52461 EAW52462 EAW52463 Q8TD43 AF497623 AAM18083 AJ575813 CAE05941 AK000048 BAA90907 AK000235 AK074664 AK292862 BAF85551 AK295820 BAG58637 AK307897 AY046396 AAL02142 AY297044 AAP44473 AY297045 AAP44474 AY297046 AAP44475 BC132727 AAI32728 BC144122 BC144123 BM857470 DA218254 XM_005259017 XP_005259074 XM_005259018 XP_005259075 XM_011527046 XP_011525348 NM_001195227 NP_001182156 NM_017636 NP_060106
Function Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NF
Subcellular Location Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus.
Tissue Specificity Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:16777713, ECO:0000269|PubMed:19726882, ECO:0000269|PubMed:20656926}.

TRPM4 (G-20) - sc-27540 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRPM4 (G-20): sc-27540. Western blot analysis of TRPM4 expression in MCF7 (A) and Jurkat (B) whole cell lysates.

TRPM4 (T-20) - sc-27539 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRPM4 (T-20): sc-27539. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

TRPM4 (H-55) - sc-67125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRPM4 (H-55): sc-67125. Western blot analysis of TRPM4 expression in MDCK whole cell lysate.

Anti-TRPM4 antibody - ab130447 from Abcam

Host Chicken
Clonality Polyclonal

Anti-TRPM4 antibody - ab62991 from Abcam

Host Sheep
Clonality Polyclonal
Ab62991 staining TRPM4 in human lung cancer cell line A549 by ICC/IF. Cells were incubated with blocking buffer (PBS containing 5% FCS) for 30 minutes at room temperature and were then incubated with primary antibody (1/100) in blocking buffer for a further 30 minutes An Alexa-488-conjugated Goat anti-sheep (1/200) was used as secondary antibody.

Anti-TRPM4 antibody - ab63090 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPM4 antibody - ab124239 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TRPM4 antibody (ab124239) at 1/100 dilution + 293 cell line lysates at 35 µg

Anti-TRPM4 Antibody (N-Terminus) IHC-plus™ - LS-A8602 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPM4 antibody LS-A8602 IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TRPM4 Antibody (C-Terminus) IHC-plus™ - LS-A8616 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPM4 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TRPM4 Antibody (aa500-600) - LS-C145025 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM4 Antibody (aa1121-1149, AP) - LS-C224476 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM4 Antibody (aa1121-1149, APC) - LS-C224477 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM4 Antibody (aa1121-1149, Biotin) - LS-C224478 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM4 Antibody (aa1121-1149, FITC) - LS-C224479 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM4 Antibody (aa1121-1149, Azide-free, HRP) - LS-C224480 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM4 Antibody (aa1121-1149, PE) - LS-C224482 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM4 Antibody (aa1120-1149) - LS-C325988 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM4 Antibody (aa359-408) - LS-C110013 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRPM4 antibody LS-C110013 Western blot of 293T cell lysate.

Anti-TRPM4 Antibody (Internal) IHC-plus™ - LS-A8605 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPM4 antibody LS-A8605 IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TRPM4 Antibody (clone 3C4) - LS-C114479 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRPM4 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRPM4.

Anti-TRPM4 Antibody (aa1121-1149) - LS-C160234 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TRPM4 Antibody western blot of 293 cell line lysates (35 ug/lane). The TRPM4 antibody detected the TRPM4 protein (arrow).

Anti-TRPM4 Antibody (clone 14C3) - LS-C114478 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 14C3
IHC of paraffin-embedded Carcinoma of liver tissue using anti-TRPM4 mouse monoclonal antibody. (Dilution 1:50).

Anti-TRPM4 Antibody (clone 14F1) - LS-C114485 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 14F1
IHC of paraffin-embedded pancreas tissue using anti-TRPM4 mouse monoclonal antibody. (Dilution 1:50).

TRPM4 Antibody (10H5) - NBP1-48036 from Novus Biologicals

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10H5
Western Blot: TRPM4 Antibody (10H5) [NBP1-48036] Analysis of extracts (35ug) from 9 different cell lines by using anti-TRPM4 monoclonal antibody.

TRPM4 Polyclonal Antibody - bs-9051R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with TRPM4 Polyclonal Antibody, Unconjugated (bs-9051R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. \r\n\r\n
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