| Gene Symbol |
TRPM4
|
| Entrez Gene |
54795
|
| Alt Symbol |
PFHB1B, TRPM4B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 4
|
| Other Description |
LTrpC4|calcium-activated non-selective cation channel 1|hTRPM4|long transient receptor potential channel 4|melastatin-4|transient receptor potential cation channel subfamily M member 4
|
| Swissprots |
Q7Z5D9 A2RU25 Q96L84 Q8TD43 Q9NXV1
|
| Accessions |
CAC69808 EAW52460 EAW52461 EAW52462 EAW52463 Q8TD43 AF497623 AAM18083 AJ575813 CAE05941 AK000048 BAA90907 AK000235 AK074664 AK292862 BAF85551 AK295820 BAG58637 AK307897 AY046396 AAL02142 AY297044 AAP44473 AY297045 AAP44474 AY297046 AAP44475 BC132727 AAI32728 BC144122 BC144123 BM857470 DA218254 XM_005259017 XP_005259074 XM_005259018 XP_005259075 XM_011527046 XP_011525348 NM_001195227 NP_001182156 NM_017636 NP_060106
|
| Function |
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NF
|
| Subcellular Location |
Isoform 1: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus.
|
| Tissue Specificity |
Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells. Prominently expressed in Purkinje fibers. Expressed at higher levels in T-helper 2 (Th2) cells as compared to T-helper 1 (Th1) cells. {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367, ECO:0000269|PubMed:15472118, ECO:0000269|PubMed:16777713, ECO:0000269|PubMed:19726882, ECO:0000269|PubMed:20656926}.
|