Gene Symbol | Mus81 |
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Entrez Gene | 293678 |
Alt Symbol | - |
Species | Rat |
Gene Type | protein-coding |
Description | MUS81 structure-specific endonuclease subunit |
Other Description | MUS81 endonuclease homolog|crossover junction endonuclease MUS81 |
Swissprots | Q4KM32 |
Accessions | EDM12499 EDM12500 Q4KM32 BC098853 AAH98853 XM_006230747 XP_006230809 XM_008760106 XP_008758328 XM_008760107 XP_008758329 NM_001025645 NP_001020816 |
Function | Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus, nucleolus. Note=Recruited to foci of DNA damage in S-phase cells. {ECO:0000250}. |
Top Pathways | Homologous recombination, Fanconi anemia pathway |
Recombinant Rat Crossover junction endonuclease MUS81(Mus81) - CSB-YP679995RA CSB-EP679995RA CSB-BP679995RA CSB-MP679995RA from Cusabio
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Recombinant Rat MUS81 Protein - MUS81-3824R from Creative Biomart
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Crossover junction endonuclease MUS81 (Mus81), Recombinant Protein - MBS1436551 from MyBioSource
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