| Gene Symbol |
Mus81
|
| Entrez Gene |
293678
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
MUS81 structure-specific endonuclease subunit
|
| Other Description |
MUS81 endonuclease homolog|crossover junction endonuclease MUS81
|
| Swissprots |
Q4KM32
|
| Accessions |
EDM12499 EDM12500 Q4KM32 BC098853 AAH98853 XM_006230747 XP_006230809 XM_008760106 XP_008758328 XM_008760107 XP_008758329 NM_001025645 NP_001020816
|
| Function |
Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus. Note=Recruited to foci of DNA damage in S-phase cells. {ECO:0000250}.
|
| Top Pathways |
Homologous recombination, Fanconi anemia pathway
|