Gene Symbol | NME5 |
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Entrez Gene | 8382 |
Alt Symbol | NM23-H5, NM23H5, RSPH23 |
Species | Human |
Gene Type | protein-coding |
Description | NME/NM23 family member 5 |
Other Description | IPIA-beta|NDK-H 5|NDP kinase homolog 5|inhibitor of p53-induced apoptosis-beta|non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)|nucleoside diphosphate kinase homolog 5|radial spoke 23 homolog|testis-specific nm23 homolog |
Swissprots | B2R5G7 P56597 |
Accessions | EAW62163 EAW62164 P56597 AF067724 AAC64358 AK312181 BAG35114 BC026182 AAH26182 BM979998 BX490554 U90450 AAC69440 Y14992 CAA75226 XM_005272099 XP_005272156 XM_006714716 XP_006714779 XM_011543662 XP_011541964 XM_011543663 XP_011541965 NM_003551 NP_003542 |
Function | Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). {ECO:0000250}. |
Tissue Specificity | Specifically expressed in testis germinal cells. |
Top Pathways | Purine metabolism, Pyrimidine metabolism |
nm23-H5 CRISPR/Cas9 KO Plasmid (h) - sc-411168 from Santa Cruz Biotechnology
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nm23-H5 HDR Plasmid (h) - sc-411168-HDR from Santa Cruz Biotechnology
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nm23-H5 Double Nickase Plasmid (h) - sc-411168-NIC from Santa Cruz Biotechnology
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nm23-H5 Double Nickase Plasmid (h2) - sc-411168-NIC-2 from Santa Cruz Biotechnology
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nm23-H5 CRISPR Activation Plasmid (h) - sc-411168-ACT from Santa Cruz Biotechnology
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nm23-H5 CRISPR Activation Plasmid (h2) - sc-411168-ACT-2 from Santa Cruz Biotechnology
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nm23-H5 Lentiviral Activation Particles (h) - sc-411168-LAC from Santa Cruz Biotechnology
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nm23-H5 Lentiviral Activation Particles (h2) - sc-411168-LAC-2 from Santa Cruz Biotechnology
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nm23-H5 siRNA (h) - sc-91797 from Santa Cruz Biotechnology
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nm23-H5 shRNA Plasmid (h) - sc-91797-SH from Santa Cruz Biotechnology
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nm23-H5 shRNA (h) Lentiviral Particles - sc-91797-V from Santa Cruz Biotechnology
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NME5 RNAi - H00008382-R02 from Novus Biologicals
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MISSION® esiRNA - EHU039001 from Sigma-Aldrich
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MISSION® siRNA - SIHK1432 from Sigma-Aldrich
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MISSION® siRNA - SIHK1434 from Sigma-Aldrich
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MISSION® siRNA - SIHK1433 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15371 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04361 from Sigma-Aldrich
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NME5 siRNA (Human) - CRH5493 from Cohesion Biosciences
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shRNA set against Human NME5 (NM_003551.2) - SHH353180 from Creative biogene
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shRNA set against Human NME5(NM_003551.2) - SHR013962 from Creative biogene
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Human NME5 siRNA - orb265995 from Biorbyt
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NME5 shRNA Plasmid (Human) - CHH5493 from Cohesion Biosciences
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NME5 miRNA 3'UTR clone - MiUTR1H-06816 from Creative biogene
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