| Gene Symbol | HPRT1 |
|---|---|
| Entrez Gene | 3251 |
| Alt Symbol | HGPRT, HPRT |
| Species | Human |
| Gene Type | protein-coding |
| Description | hypoxanthine phosphoribosyltransferase 1 |
| Other Description | HGPRTase|hypoxanthine-guanine phosphoribosyltransferase |
| Swissprots | A6NHF0 B2R8M9 P00492 |
| Accessions | AAA36012 AAA52691 AAB21289 AAV31777 EAX11760 EAX11761 P00492 AK313435 BAG36226 BC000578 AAH00578 BT019350 AAV38157 CR407645 CAG28573 DQ895107 ABM86033 DQ895109 ABM86035 EU176316 ABW03767 EU176655 ABW03456 L29382 AAB59392 L29383 AAB59391 M24772 M31642 AAA52690 S60300 AAC60591 XM_011531328 XP_011529630 NM_000194 NP_000185 |
| Function | Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
| Subcellular Location | Cytoplasm. |
| Top Pathways | Purine metabolism, Drug metabolism - other enzymes |