DMBT1
| Gene Symbol | DMBT1 |
|---|---|
| Entrez Gene | 1755 |
| Alt Symbol | GP340, muclin |
| Species | Human |
| Gene Type | protein-coding |
| Description | deleted in malignant brain tumors 1 |
| Other Description | SAG|deleted in malignant brain tumors 1 protein|glycoprotein 340|gp-340|hensin|salivary agglutinin|surfactant pulmonary-associated D-binding protein |
| Swissprots | A6NDJ5 Q9UJ57 Q59EX0 B1ARF0 Q9UGM2 A6NDG4 A8E4R5 Q5JR26 B7Z8Y2 Q6MZN4 B1ARE7 Q96DU4 Q9UGM3 B1ARE8 Q9Y4V9 B1ARE9 Q9UKJ4 Q9Y211 F8WEF7 |
| Accessions | BAA78577 CAB63941 CAB72255 CCQ43261 EAW49308 EAW49309 EAW49310 EAW49311 Q9UGM3 AB209691 BAD92928 AF159456 AAD49696 AJ000342 CAA04019 AJ243212 CAB56155 AJ243224 CAB63942 AJ297935 CAC44122 AK304128 BAG65024 AK304149 BAH14118 BC153299 AAI53300 BX640988 CAE45995 FJ234410 ACI95281 XM_006717660 XP_006717723 XM_006717665 XP_006717728 XM_011539388 XP_011537690 XM_011539389 XP_011537691 XM_011539390 XP_011537692 XM_011539391 XP_011537693 XM_011539392 XP_011537694 XM_011539393 XP_011537695 XM_011539394 XP_011537696 XM_011539395 XP_011537697 XM_011539396 XP_011537698 XM_011539397 XP_011537699 XM_011539398 XP_011537700 XM_011539399 XP_011537701 XM_011539400 XP_011537702 XM_011539401 XP_011537703 XM_011539402 XP_011537704 XM_011539403 XP_011537705 XM_011539404 XP_011537706 XM_011539405 XP_011537707 XM_011539406 XP_011537708 XM_011539407 XP_011537709 XM_011539408 XP_011537710 XM_011539409 XP_011537711 XM_011539410 XP_011537712 XM_011539411 XP_011537713 XM_011539412 XP_011537714 XM_011539413 XP_011537715 XM_011539414 XP_011537716 XM_011539415 XP_011537717 NM_004406 NP_004397 NM_007329 NP_015568 NM_017579 NP_060049 |
| Function | May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Bi |
| Subcellular Location | Secreted {ECO:0000250}. Note=Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Iso |
| Top Pathways | Salivary secretion |
DMBT1 CRISPR/Cas9 KO Plasmid (h) - sc-402615 from Santa Cruz Biotechnology
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DMBT1 HDR Plasmid (h) - sc-402615-HDR from Santa Cruz Biotechnology
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DMBT1 Double Nickase Plasmid (h) - sc-402615-NIC from Santa Cruz Biotechnology
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DMBT1 Double Nickase Plasmid (h2) - sc-402615-NIC-2 from Santa Cruz Biotechnology
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DMBT1 CRISPR Activation Plasmid (h) - sc-402615-ACT from Santa Cruz Biotechnology
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DMBT1 CRISPR Activation Plasmid (h2) - sc-402615-ACT-2 from Santa Cruz Biotechnology
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DMBT1 Lentiviral Activation Particles (h) - sc-402615-LAC from Santa Cruz Biotechnology
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DMBT1 Lentiviral Activation Particles (h2) - sc-402615-LAC-2 from Santa Cruz Biotechnology
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DMBT1 siRNA (h) - sc-35196 from Santa Cruz Biotechnology
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DMBT1 shRNA Plasmid (h) - sc-35196-SH from Santa Cruz Biotechnology
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DMBT1 shRNA (h) Lentiviral Particles - sc-35196-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU097001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2374 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2374 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02266 from Sigma-Aldrich
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DMBT1 siRNA (Human) - CRH1218 from Cohesion Biosciences
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DMBT1/GP340 RNAi - H00001755-R04 from Novus Biologicals
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DMBT1/GP340 RNAi - H00001755-R05 from Novus Biologicals
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DMBT1/GP340 RNAi - H00001755-R06 from Novus Biologicals
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DMBT1 - MBS8201488 from MyBioSource
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shRNA set against Human DMBT1 (NM_004406.2) - SHH278749 from Creative biogene
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shRNA set against Human DMBT1(NM_007329.2) - SHH007715 from Creative biogene
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shRNA set against Human DMBT1(NM_017579.2) - SHH007733 from Creative biogene
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shRNA set against Human DMBT1(NM_004406.2) - SHH007751 from Creative biogene
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Human DMBT1 siRNA - orb261720 from Biorbyt
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